Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.47 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 2/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5133956 | 0.94 | SMN1; SMN2 (0.48) | TSHRSMN1; SMN2LMNAGPR119CHRNA7 | |
| SCHEMBL2300194 | 0.90 | SMN1; SMN2 (0.50) | TSHRSMN1; SMN2LMNAGPR119CHRNA7 | |
| SCHEMBL387140 | 0.88 | GPR119 (0.64) | TSHRSMN1; SMN2LMNAGPR119 | |
| SCHEMBL27951676 | 0.85 | GPR119 (0.47) | TSHRSMN1; SMN2LMNAGPR119CHRNA7 | |
| SCHEMBL2298624 | 0.84 | NPC1 (0.56) | TSHRSMN1; SMN2LMNAGPR119CHRNA7 | |
| SCHEMBL389126 | 0.82 | GPR119 (0.66) | TSHRSMN1; SMN2LMNAGPR119 | |
| SCHEMBL1831648 | 0.79 | GPR119 (0.48) | TSHRSMN1; SMN2LMNAGPR119CHRNA7 | |
| SCHEMBL2292951 | 0.79 | GPR119 (0.49) | TSHRSMN1; SMN2LMNAGPR119CHRNA7 | |
| SCHEMBL389773 | 0.78 | GPR119 (0.68) | TSHRSMN1; SMN2LMNAGPR119 | |
| Tert-Butyl Formate SCHEMBL27951678 | 0.76 | SLC6A2 (0.46) | TSHRSMN1; SMN2LMNAGPR119THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2322150-A2 | Method of identifying GLP-1 secretagogues | Arena Pharmaceuticals, Inc. (US) | 2011-05-18 | — | — | EP | disclosed |
| EP-2004157-B1 | USE OF GPR119 RECEPTOR AGONISTS FOR INCREASING BONE MASS AND FOR TREATING OSTEOPOROSIS, AS WELL AS COMBINATION THERAPY RELATING THERETO | ARENA PHARM INC (US) | 2011-01-12 | — | — | EP | disclosed |
| EP-2253311-A2 | Use of GPR119 receptor agonists for increasing bone mass and for treating osteoporosis, as well as combination therapy relating thereto | Arena Pharmaceuticals, Inc. (US) | 2010-11-24 | — | — | EP | disclosed |