Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 4/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | TLR4 | O00206 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | TYMS | P04818 | 1/20 | 0.56 |
| ▸ | GLA | P06280 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | FOLR2 | P14207 | 1/20 | 0.56 |
| ▸ | FOLR1 | P15328 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.56 |
| ▸ | GART | P22102 | 1/20 | 0.56 |
| ▸ | APEX1 | P27695 | 1/20 | 0.56 |
| ▸ | CASP1 | P29466 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10697242 | 0.91 | DHFR (0.63) | DHFRKDM4ETLR4MEN1ALDH1A1 | |
| SCHEMBL19918280 | 0.85 | DHFR (0.76) | DHFRKDM4ETLR4MEN1ALDH1A1 | |
| SCHEMBL16546067 | 0.85 | DHFR (0.76) | DHFRKDM4ETLR4MEN1ALDH1A1 | |
| SCHEMBL29711336 | 0.85 | DHFR (0.76) | DHFRKDM4ETLR4MEN1ALDH1A1 | |
| SCHEMBL19918327 | 0.85 | DHFR (0.76) | DHFRKDM4ETLR4MEN1ALDH1A1 | |
| SCHEMBL15159356 | 0.81 | DHFR (0.67) | DHFRKDM4ETLR4MEN1ALDH1A1 | |
| SCHEMBL22879104 | 0.80 | FPGS (0.86) | DHFRKDM4ETLR4MEN1ALDH1A1 | |
| SCHEMBL13668065 | 0.80 | FPGS (0.86) | DHFRKDM4ETLR4MEN1ALDH1A1 | |
| SCHEMBL14499671 | 0.79 | DHFR (0.71) | DHFRKDM4ETLR4MEN1ALDH1A1 | |
| SCHEMBL15469224 | 0.79 | DHFR (0.87) | DHFRKDM4ETLR4MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4725687-A | ANTITUMOR AGENTS; SIDE EFFECT REDUCTION; POTENCY | SOUTHERN RESEARCH INSTITUTE (US) | 1988-02-16 | — | — | US | claimed |
| US-4725687-A | ANTITUMOR AGENTS; SIDE EFFECT REDUCTION; POTENCY | SOUTHERN RESEARCH INSTITUTE (US) | 1988-02-16 | — | — | US | disclosed |