Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 14/20 | 0.77 |
| ▸ | HTR2C | P28335 | 8/20 | 0.77 |
| ▸ | HTR1D | P28221 | 4/20 | 0.77 |
| ▸ | HTR1B | P28222 | 4/20 | 0.77 |
| ▸ | HTR5A | P47898 | 3/20 | 0.77 |
| ▸ | HTR2A | P28223 | 3/20 | 0.77 |
| ▸ | HTR7 | P34969 | 2/20 | 0.77 |
| ▸ | HTR2B | P41595 | 2/20 | 0.77 |
| ▸ | HTR1E | P28566 | 1/20 | 0.77 |
| ▸ | HTR1F | P30939 | 1/20 | 0.77 |
| ▸ | HTR3A | P46098 | 1/20 | 0.77 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.77 |
| ▸ | HTR6 | P50406 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
| ▸ | MPO | P05164 | 1/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL10691878 | 0.95 | HTR1A (0.70) | HTR1AHTR2CHTR1DHTR1BHTR5A | |
| Hydrochloric Acid SCHEMBL9800422 | 0.93 | HTR1A (0.77) | HTR1AHTR2CHTR1DHTR1BHTR5A | |
| Hydrochloric Acid SCHEMBL9800405 | 0.93 | HTR1A (0.77) | HTR1AHTR2CHTR1DHTR1BHTR5A | |
| SCHEMBL9800349 | 0.93 | HTR1A (0.80) | HTR1AHTR2CHTR1DHTR1BHTR5A | |
| Hydrochloric Acid SCHEMBL9800365 | 0.92 | HTR1A (0.79) | HTR1AHTR2CHTR1DHTR1BHTR5A | |
| Oxalic Acid SCHEMBL9800389 | 0.88 | HTR1A (0.72) | HTR1AHTR2CHTR1DHTR1BHTR5A | |
| Sumatriptan SCHEMBL183393 | 0.87 | HTR1A (1.00) | HTR1AHTR2CHTR1DHTR1BHTR5A | |
| Sumatriptan SCHEMBL29450235 | 0.87 | HTR1A (1.00) | HTR1AHTR2CHTR1DHTR1BHTR5A | |
| Sumatriptan SCHEMBL1482 | 0.87 | HTR1A (1.00) | HTR1AHTR2CHTR1DHTR1BHTR5A | |
| Sumatriptan SCHEMBL4916383 | 0.86 | HTR1A (0.98) | HTR1AHTR2CHTR1DHTR1BHTR5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4785016-A | VASOCONSTRICTION, MIGRAINES ALKANEAMINO, ALKANE SULFONAMIDE INDOLES | GLAXO GROUP LIMITED (GB) | 1988-11-15 | — | — | US | disclosed |