Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | CA6 | P23280 | 2/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.39 |
| ▸ | CA3 | P07451 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 4/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | NT5E | P21589 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5312986 | 0.97 | MAPT (0.44) | MAPTMEN1KMT2AALDH1A1CYP3A4 | |
| SCHEMBL3146022 | 0.86 | ACHE (0.56) | MAPTMEN1KMT2AALDH1A1CYP3A4 | |
| SCHEMBL11859127 | 0.86 | CA1 (0.33) | CA1CA2 | |
| SCHEMBL3161559 | 0.85 | TSHR (0.46) | MAPTMEN1KMT2AALDH1A1CYP3A4 | |
| SCHEMBL9153089 | 0.83 | CA1 (0.36) | ALDH1A1CYP3A4CYP2C9CA1CA2 | |
| Aniline SCHEMBL17294827 | 0.80 | TSHR (0.52) | MAPTMEN1KMT2AALDH1A1CYP3A4 | |
| Sulfurous Acid SCHEMBL27998330 | 0.77 | MAPT (0.53) | MAPTMEN1KMT2AALDH1A1CYP3A4 | |
| SCHEMBL3157755 | 0.77 | ACHE (0.50) | MAPTMEN1KMT2AALDH1A1CYP3A4 | |
| SCHEMBL10606718 | 0.75 | ESR1 (0.35) | — | |
| SCHEMBL3015878 | 0.74 | CYP2A6 (0.42) | MEN1KMT2AALDH1A1ALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4743619-A | RIFAMYCINS, POLYMERASE INHIBITION | AMERICAN HOME PRODUCTS CORPORATION (US) | 1988-05-10 | — | — | US | disclosed |
| WO-1987001280-A1 | METHOD OF TREATING HEPATITIS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1987-03-12 | — | — | WO | disclosed |
| EP-0213935-A2 | Rifamycin derivatives for treating hepatitis | AMERICAN HOME PRODUCTS CORPORATION (US) | 1987-03-11 | — | — | EP | disclosed |