SCHEMBL10691535

SCHEMBL10691535

N#Cc1ccc(COc2ccc(-c3ccc(C4Cc5ccccc5C(c5c(O)c6ccccc6oc5=O)C4)cc3)cc2)cc1

nearest known ligand 0.67

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
VKORC1 Q9BQB6 1/20 0.67
MAOB P27338 10/20 0.42
ACHE P22303 3/20 0.39
MAOA P21397 4/20 0.39
PRKDC P78527 2/20 0.38
KDM4E B2RXH2 2/20 0.38
MEN1 O00255 1/20 0.38
CYP1A2 P05177 1/20 0.38
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38
KMT2A Q03164 1/20 0.38
NQO1 P15559 2/20 0.38
ALDH1A1 P00352 1/20 0.36
RECQL P46063 1/20 0.36
PTPN1 P18031 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10688883 0.93 VKORC1 (0.71) VKORC1MAOBACHEMAOAKDM4E
SCHEMBL10693000 0.93 VKORC1 (0.71) VKORC1MAOBACHEMAOAKDM4E
SCHEMBL10692706 0.91 VKORC1 (0.82) VKORC1MAOBMAOAKDM4ENQO1
SCHEMBL10694018 0.91 VKORC1 (0.82) VKORC1MAOBMAOAKDM4ENQO1
SCHEMBL10691142 0.89 VKORC1 (0.65) VKORC1MAOBMAOAKDM4EMEN1
SCHEMBL10680674 0.87 VKORC1 (0.62) VKORC1MAOBMAOAKDM4EMEN1
SCHEMBL53492 0.87 VKORC1 (0.62) VKORC1MAOBMAOAKDM4EMEN1
SCHEMBL29387562 0.87 VKORC1 (0.62) VKORC1MAOBMAOAKDM4EMEN1
SCHEMBL20530982 0.87 VKORC1 (0.62) VKORC1MAOBMAOAKDM4EMEN1
SCHEMBL20530990 0.87 VKORC1 (0.62) VKORC1MAOBMAOAKDM4EMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4748185-A RODENTICIDES E. I. DU PONT DE NEMOURS AND COMPANY (US) 1988-05-31 US disclosed