Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.45 |
| ▸ | GPR183 | P32249 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15157067 | 0.82 | NOTUM (0.52) | SMN1; SMN2NPSR1KMT2ANOTUMNPC1 | |
| SCHEMBL17830713 | 0.81 | USP2 (0.44) | SMN1; SMN2LMNAKMT2ANOTUMCYP1A2 | |
| SCHEMBL21760453 | 0.73 | ALDH1A1 (0.54) | SMN1; SMN2KMT2ANOTUMNPC1CYP1A2 | |
| SCHEMBL20083679 | 0.70 | ALDH1A1 (0.63) | NPSR1KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL17653866 | 0.69 | KMT2A (0.57) | LMNAKMT2ACYP2C9CYP2C19MEN1 | |
| SCHEMBL3182417 | 0.69 | HDAC6 (0.56) | HDAC6POLB | |
| SCHEMBL11100594 | 0.69 | NPSR1 (0.47) | SMN1; SMN2LMNANPSR1KMT2AMEN1 | |
| SCHEMBL23298275 | 0.69 | GSK3A (0.57) | LMNAKMT2ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL6283032 | 0.69 | GSK3A (0.56) | KMT2ACYP1A2CYP2C9CYP2C19POLB | |
| SCHEMBL25426510 | 0.68 | ALDH1A1 (0.54) | SMN1; SMN2NPSR1KMT2ANOTUMNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0252713-A1 | Indolinone derivatives | PFIZER INC. (US) | 1988-01-13 | — | — | EP | disclosed |