Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 2/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.43 |
| ▸ | DHFR | P00374 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27655874 | 0.83 | PDE5A (0.50) | PDE5AAURKAALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL31648353 | 0.79 | HSP90AA1 (0.51) | ALDH1A1HPGDSMN1; SMN2MEN1KMT2A | |
| SCHEMBL8129903 | 0.79 | FGFR1 (0.59) | ALDH1A1HSP90AA1PDGFRBPDGFRAHSP90AB1 | |
| SCHEMBL3206489 | 0.77 | AKT1 (0.43) | AURKAPDGFRBPDGFRATLR8 | |
| SCHEMBL28280374 | 0.75 | FGFR1 (0.51) | MEN1KMT2ADHFRMAP4K4 | |
| SCHEMBL31520474 | 0.75 | FGFR1 (0.51) | MEN1KMT2ADHFRMAP4K4 | |
| SCHEMBL31648322 | 0.75 | FGFR1 (0.45) | AURKAHSP90AA1PDGFRBPDGFRAHSP90AB1 | |
| SCHEMBL6065171 | 0.74 | ALDH1A1 (0.53) | PDE5AAURKAALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL3195819 | 0.74 | PDGFRB (0.40) | ALDH1A1HPGDSMN1; SMN2MEN1KMT2A | |
| SCHEMBL27526791 | 0.73 | ALDH1A1 (0.56) | PDE5AAURKAALDH1A1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4720500-A | N-1,8-naphthyridin-2-yl amides useful as immunostimulants | RHONE-POULENC SANTE (FR) | 1988-01-19 | — | — | US | disclosed |