Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 5/20 | 0.62 |
| ▸ | GABRA5 | P31644 | 5/20 | 0.62 |
| ▸ | GABRA2 | P47869 | 5/20 | 0.62 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.62 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.62 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.62 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.62 |
| ▸ | HTR2A | P28223 | 1/20 | 0.62 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.62 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.62 |
| ▸ | PTAFR | P25105 | 9/20 | 0.60 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CNR1 | P21554 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10694252 | 0.88 | GABRA1 (0.58) | GABRA1GABRA5GABRA2GABRA3OPRK1 | |
| SCHEMBL10695202 | 0.86 | GABRA1 (0.62) | GABRA1GABRA5GABRA2GABRA3OPRK1 | |
| SCHEMBL9654306 | 0.86 | GABRA1 (0.64) | GABRA1GABRA5GABRA2GABRA3OPRK1 | |
| SCHEMBL10696323 | 0.81 | GABRA1 (0.66) | GABRA1GABRA5GABRA2GABRA3OPRK1 | |
| SCHEMBL10691840 | 0.81 | PTAFR (0.68) | GABRA1GABRA5GABRA2GABRA3OPRK1 | |
| SCHEMBL9653882 | 0.78 | GABRA1 (0.73) | GABRA1GABRA5GABRA2GABRA3OPRK1 | |
| SCHEMBL10695715 | 0.78 | GABRA1 (0.69) | GABRA1GABRA5GABRA2GABRA3OPRK1 | |
| SCHEMBL11681893 | 0.78 | GABRA1 (0.69) | GABRA1GABRA5GABRA2GABRA3OPRK1 | |
| SCHEMBL9653696 | 0.78 | GABRA1 (0.69) | GABRA1GABRA5GABRA2GABRA3OPRK1 | |
| SCHEMBL10693287 | 0.78 | GABRA1 (0.80) | GABRA1GABRA5GABRA2GABRA3OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0255028-A2 | 1,4-Benzodiazepines, their preparation and use as PAF antagonists | BOEHRINGER INGELHEIM KG (DE) | 1988-02-03 | — | — | EP | disclosed |