Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.59 |
| ▸ | HTR2C | P28335 | 4/20 | 0.59 |
| ▸ | HTR2B | P41595 | 4/20 | 0.59 |
| ▸ | DRD1 | P21728 | 12/20 | 0.55 |
| ▸ | DRD5 | P21918 | 6/20 | 0.55 |
| ▸ | DRD2 | P14416 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ADCY6 | O43306 | 1/20 | 0.44 |
| ▸ | ADCY3 | O60266 | 1/20 | 0.44 |
| ▸ | ADCY9 | O60503 | 1/20 | 0.44 |
| ▸ | ADCY5 | O95622 | 1/20 | 0.44 |
| ▸ | ADCY8 | P40145 | 1/20 | 0.44 |
| ▸ | ADCY7 | P51828 | 1/20 | 0.44 |
| ▸ | ADCY2 | Q08462 | 1/20 | 0.44 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.44 |
| ▸ | ADCY4 | Q8NFM4 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10692816 | 0.99 | HTR2A (0.58) | HTR2AHTR2CHTR2BDRD1DRD5 | |
| SCHEMBL11103719 | 0.87 | DRD1 (0.70) | HTR2AHTR2CHTR2BDRD1DRD5 | |
| SCHEMBL11103721 | 0.87 | DRD1 (0.70) | HTR2AHTR2CHTR2BDRD1DRD5 | |
| SCHEMBL11103715 | 0.87 | DRD1 (0.70) | HTR2AHTR2CHTR2BDRD1DRD5 | |
| SCHEMBL10691620 | 0.83 | HTR2C (0.60) | HTR2AHTR2CHTR2BDRD1DRD5 | |
| SCHEMBL10693049 | 0.83 | HTR2C (0.60) | HTR2AHTR2CHTR2BDRD1DRD5 | |
| SCHEMBL29558201 | 0.83 | DRD1 (0.76) | DRD1DRD5DRD2KDM4EHPGD | |
| SCHEMBL8769399 | 0.83 | HTR2A (0.63) | HTR2AHTR2CHTR2BDRD1DRD5 | |
| Hydrochloric Acid SCHEMBL10691613 | 0.82 | HTR2A (0.59) | HTR2AHTR2CHTR2BDRD1DRD5 | |
| Hydrochloric Acid SCHEMBL10690789 | 0.82 | DRD1 (0.74) | DRD1DRD5DRD2KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4751222-A | 2,3,4,5-tetrahydro-1H-3-benzazepines and CNS affecting use thereof | NOVO INDUSTRI A/S (DK) | 1988-06-14 | — | — | US | disclosed |
| EP-0200455-A2 | 2,3,4,5-tetrahydro-1H-3-benzazepines substituted in position 5 | NOVO NORDISK A/S (DK) | 1986-11-05 | — | — | EP | disclosed |