Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1C | Q13936 | 13/20 | 0.64 |
| ▸ | CACNA1F | O60840 | 11/20 | 0.60 |
| ▸ | CACNA1D | Q01668 | 11/20 | 0.60 |
| ▸ | CACNA1S | Q13698 | 11/20 | 0.60 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9825229 | 0.93 | CACNA1C (0.56) | CACNA1CCACNA1FCACNA1DCACNA1SADORA3 | |
| SCHEMBL9617651 | 0.92 | CACNA1C (0.55) | CACNA1CCACNA1FCACNA1DCACNA1SADORA3 | |
| SCHEMBL7287257 | 0.91 | ADORA3 (0.53) | CACNA1CCACNA1FCACNA1DCACNA1SADORA3 | |
| SCHEMBL10488477 | 0.89 | ADORA3 (0.61) | CACNA1CCACNA1FCACNA1DCACNA1SADORA3 | |
| SCHEMBL7512934 | 0.88 | ADORA3 (0.52) | CACNA1CCACNA1FCACNA1DCACNA1SADORA3 | |
| SCHEMBL9825233 | 0.86 | CACNA1C (0.56) | CACNA1CCACNA1FCACNA1DCACNA1SADORA3 | |
| SCHEMBL11783182 | 0.86 | CACNA1C (0.66) | CACNA1CCACNA1FCACNA1DCACNA1SADORA3 | |
| SCHEMBL9831174 | 0.85 | CACNA1C (0.71) | CACNA1CCACNA1FCACNA1DCACNA1SADORA3 | |
| SCHEMBL9825000 | 0.85 | ADORA3 (0.54) | CACNA1CCACNA1FCACNA1DCACNA1SADORA3 | |
| SCHEMBL9484992 | 0.83 | CACNA1C (0.53) | CACNA1CCACNA1FCACNA1DCACNA1SADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4727082-A | CARDIOVASCULAR DISORDERS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1988-02-23 | — | — | US | disclosed |
| EP-0167371-A2 | Dihydropyridine compounds, their production, and pharmaceutical compositions containing them | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1986-01-08 | — | — | EP | disclosed |