Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.42 |
| ▸ | CCR5 | P51681 | 1/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10679045 | 0.83 | GAA (0.42) | TDP1TSHRALDH1A1 | |
| SCHEMBL3483564 | 0.81 | HTT (0.48) | TDP1HTTTSHRMAPTMAPK1 | |
| SCHEMBL10693088 | 0.81 | TDP1 (0.50) | TDP1HTTTSHRMAPTMAPK1 | |
| SCHEMBL12130666 | 0.81 | CNR2 (0.51) | TDP1HTTTSHRMAPTMAPK1 | |
| SCHEMBL5191924 | 0.81 | TDP1 (0.67) | TDP1HTTTSHRMAPTMAPK1 | |
| SCHEMBL3922749 | 0.79 | TDP1 (0.47) | TDP1HTTTSHRMAPTMAPK1 | |
| SCHEMBL18997833 | 0.79 | MAPK1 (0.52) | TDP1HTTTSHRMAPTMAPK1 | |
| SCHEMBL3917401 | 0.79 | TDP1 (0.47) | TDP1HTTTSHRMAPTMAPK1 | |
| SCHEMBL27700771 | 0.78 | TDP1 (0.58) | TDP1HTTTSHRMAPTMAPK1 | |
| SCHEMBL3653180 | 0.78 | ESR2 (0.50) | TDP1HTTTSHRMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0260901-A1 | Benzenesulphonamides useful as anti-arrythmic agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1988-03-23 | — | — | EP | claimed |