Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
| ▸ | CCR5 | P51681 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 2/20 | 0.40 |
| ▸ | CA9 | Q16790 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.40 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.40 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.40 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5191924 | 0.83 | TDP1 (0.67) | TDP1ESR1HTTMAPTTSHR | |
| SCHEMBL10693087 | 0.81 | TDP1 (0.46) | TDP1ESR1HTTMAPTTSHR | |
| SCHEMBL27700771 | 0.81 | TDP1 (0.58) | TDP1ESR1HTTMAPTTSHR | |
| SCHEMBL9835822 | 0.80 | CYP2C9 (0.46) | MEN1KMT2AHTTMAPTTSHR | |
| SCHEMBL3483564 | 0.78 | HTT (0.48) | TDP1KMT2AESR1HTTMAPT | |
| SCHEMBL12130666 | 0.77 | CNR2 (0.51) | TDP1HTTMAPTTSHRMAPK1 | |
| SCHEMBL3922749 | 0.75 | TDP1 (0.47) | TDP1KMT2AHTTMAPTTSHR | |
| SCHEMBL18997833 | 0.75 | MAPK1 (0.52) | TDP1MEN1KMT2AHTTMAPT | |
| SCHEMBL3917401 | 0.75 | TDP1 (0.47) | TDP1KMT2AESR1HTTMAPT | |
| SCHEMBL3653180 | 0.74 | ESR2 (0.50) | TDP1KMT2AESR1HTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0260901-A1 | Benzenesulphonamides useful as anti-arrythmic agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1988-03-23 | — | — | EP | claimed |