Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 2/20 | 0.74 |
| ▸ | HRAS | P01112 | 14/20 | 0.71 |
| ▸ | ESR1 | P03372 | 14/20 | 0.71 |
| ▸ | ESR2 | Q92731 | 13/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.70 |
| ▸ | POLB | P06746 | 1/20 | 0.70 |
| ▸ | MAPT | P10636 | 1/20 | 0.70 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.70 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10693314 | 0.99 | TOP1 (0.72) | TOP1HRASESR1ESR2KDM4E | |
| SCHEMBL30469493 | 0.87 | HRAS (0.79) | TOP1HRASESR1ESR2KDM4E | |
| SCHEMBL14267762 | 0.87 | TOP1 (0.74) | TOP1HRASESR1ESR2KDM4E | |
| Netropsin SCHEMBL197747 | 0.87 | TOP1 (0.74) | TOP1HRASESR1ESR2KDM4E | |
| Netropsin SCHEMBL10408939 | 0.86 | TOP1 (0.72) | TOP1HRASESR1ESR2KDM4E | |
| Netropsin SCHEMBL4953090 | 0.86 | TOP1 (0.72) | TOP1HRASESR1ESR2KDM4E | |
| SCHEMBL27277236 | 0.85 | TOP1 (0.56) | TOP1HRASESR1ESR2KDM4E | |
| SCHEMBL7510361 | 0.85 | HRAS (0.76) | TOP1HRASESR1ESR2KDM4E | |
| SCHEMBL27279000 | 0.85 | TOP1 (0.56) | TOP1HRASESR1ESR2KDM4E | |
| SCHEMBL27277511 | 0.85 | TOP1 (0.56) | TOP1HRASESR1ESR2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4766142-A | ANTICARCINOGENIC AGENTS | FARMITALIA CARLO ERBA S.R.L. (IT) | 1988-08-23 | — | — | US | disclosed |