Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 2/20 | 0.74 |
| ▸ | HRAS | P01112 | 14/20 | 0.71 |
| ▸ | ESR1 | P03372 | 13/20 | 0.71 |
| ▸ | ESR2 | Q92731 | 13/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.70 |
| ▸ | POLB | P06746 | 1/20 | 0.70 |
| ▸ | MAPT | P10636 | 1/20 | 0.70 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.70 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.34 |
| ▸ | PRKCA | P17252 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14267762 | 1.00 | TOP1 (0.74) | TOP1HRASESR1ESR2KDM4E | |
| Netropsin SCHEMBL4953090 | 0.99 | TOP1 (0.72) | TOP1HRASESR1ESR2KDM4E | |
| Netropsin SCHEMBL10408939 | 0.99 | TOP1 (0.72) | TOP1HRASESR1ESR2KDM4E | |
| Netropsin SCHEMBL951644 | 0.98 | TOP1 (0.71) | TOP1HRASESR1ESR2KDM4E | |
| SCHEMBL12348338 | 0.98 | TOP1 (0.70) | TOP1HRASESR1ESR2KDM4E | |
| SCHEMBL12348157 | 0.94 | TOP1 (0.65) | TOP1HRASESR1ESR2KDM4E | |
| SCHEMBL19288091 | 0.91 | TOP1 (0.62) | TOP1HRASESR1ESR2KDM4E | |
| Netropsin SCHEMBL4284668 | 0.89 | TOP1 (0.60) | TOP1HRASESR1ESR2KDM4E | |
| SCHEMBL30469493 | 0.87 | HRAS (0.79) | TOP1HRASESR1ESR2KDM4E | |
| SCHEMBL10693609 | 0.87 | TOP1 (0.74) | TOP1HRASESR1ESR2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 4767 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4676543-A1 | METHODS OF TREATING CANCER USING ANTI-HER2 ANTIBODY-DRUG CONJUGATES AND HER2 KINASE INHIBITORS | Seagen Inc. (US) | 2026-01-14 | — | — | EP | claimed |
| EP-4667572-A2 | THERAPEUTIC TREATMENT OF MICROSATELLITE UNSTABLE CANCERS | The Broad Institute Inc. (US) | 2025-12-24 | — | — | EP | claimed |
| US-20250302974-A1 | LECTIN-DRUG CONJUGATES | UNICHEM LAB LTD (IN) | 2025-10-02 | — | — | US | claimed |
| EP-3802557-B1 | THERAPEUTIC TREATMENT OF MICROSATELLITE UNSTABLE CANCERS | BROAD INST INC (US) | 2025-08-06 | — | — | EP | claimed |
| WO-2025059144-A1 | DYNAMIC NANOMECHANICAL AMPLIFICATION ANTENNA AND USES | SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 2025-03-20 | — | — | WO | claimed |
| WO-2025055598-A1 | METHODS OF TREATING CANCER USING ANTI-HER2 ANTIBODY-DRUG CONJUGATES AND ANTI-PD-1 ANTIBODIES | REMEGEN CO., LTD. (CN) | 2025-03-20 | — | — | WO | claimed |
| WO-2025054918-A1 | METHODS OF TREATING CANCER USING ANTI-HER2 ANTIBODY-DRUG CONJUGATES AND ANTI-PD-1 ANTIBODIES | REMEGEN CO., LTD. (CN) | 2025-03-20 | — | — | WO | claimed |
| WO-2025055589-A1 | METHODS OF TREATING CERVICAL CANCER USING ANTI-HER2 ANTIBODY-DRUG CONJUGATES | REMEGEN CO., LTD. (CN) | 2025-03-20 | — | — | WO | claimed |
| WO-2025054916-A1 | METHODS OF TREATING CERVICAL CANCER USING ANTI-HER2 ANTIBODY-DRUG CONJUGATES | REMEGEN CO., LTD. (CN) | 2025-03-20 | — | — | WO | claimed |
| US-12246004-B2 | Therapeutic treatment of microsatellite unstable cancers | THE BROAD INSTITUTE, INC. (US) | 2025-03-11 | — | — | US | claimed |
| US-5272056-A | Modification of DNA and oligonucleotides using metal complexes of polyaza ligands | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 1993-12-21 | — | — | US | claimed |
| US-5204238-A | Binding an antibiotic on or near the star sequences of the restriction enzyme being used for the specific cleavage of DNA | BOEHRINGER MANNHEIM GMBH (DE) | 1993-04-20 | — | — | US | claimed |
| EP-0535458-A1 | Photochemically reactive initiators for the radical polymerization | BAYER AG (DE) | 1993-04-07 | — | — | EP | claimed |
| WO-1992020698-A1 | SEQUENCE SPECIFIC DNA BINDING DRUGS | UAB RESEARCH FOUNDATION (US) | 1992-11-26 | — | — | WO | claimed |
| EP-0497875-A1 | 2' MODIFIED OLIGONUCLEOTIDES | GILEAD SCIENCES, INC. (US) | 1992-08-12 | — | — | EP | claimed |
| EP-0450594-A2 | DNA probe signal amplification | Segev, David (US) | 1991-10-09 | — | — | EP | claimed |
| EP-0449178-A2 | Method for the reduction of star activity | Roche Diagnostics GmbH (DE) | 1991-10-02 | — | — | EP | claimed |
| WO-1991006556-A1 | 2' MODIFIED OLIGONUCLEOTIDES | GILEAD SCIENCES, INC. (US) | 1991-05-16 | — | — | WO | claimed |
| US-4960694-A | MIXING THE CENTRIFUGED PLASMA WITH AN ANTIBIOTIC OF PYRROLE-AMIDINE SERIES DISSOLVED IN BUFFER SOLUTION TO FORM REACTION PRECIPITATES | ECKARDT KLAUS (DD) | 1990-10-02 | — | — | US | claimed |
| EP-0253255-A2 | Method and test kit for the detection of fibrin monomers in the blood | ARZNEIMITTELWERK DRESDEN GmbH (DE) | 1988-01-20 | — | — | EP | claimed |