Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | PGR | P06401 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KDM4A | O75164 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10708746 | 0.84 | MAPT (0.50) | MAPTLMNAPGRTP53MEN1 | |
| SCHEMBL10695610 | 0.81 | MAPT (0.51) | MAPTLMNATP53MEN1KDM4A | |
| SCHEMBL10695502 | 0.80 | MAPT (0.49) | MAPTALDH1A1LMNATP53MEN1 | |
| SCHEMBL10697280 | 0.79 | KMT2A (0.48) | MAPTLMNATP53MEN1KDM4A | |
| SCHEMBL10706414 | 0.79 | MAPT (0.48) | MAPTLMNATP53MEN1KDM4A | |
| SCHEMBL16315749 | 0.78 | ELANE (0.59) | ELANEMAPTALDH1A1LMNATP53 | |
| SCHEMBL13233765 | 0.77 | ELANE (0.58) | ELANEMAPTALDH1A1PGRTP53 | |
| SCHEMBL7377135 | 0.77 | ELANE (0.51) | ELANEMAPTALDH1A1LMNATP53 | |
| SCHEMBL2492094 | 0.77 | MAPT (0.57) | MAPTTP53MEN1KDM4APOLB | |
| SCHEMBL14609254 | 0.77 | ELANE (0.54) | ELANEMAPTALDH1A1LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |