Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | THRB | P10828 | 2/20 | 0.48 |
| ▸ | KDM4A | O75164 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | HSPA9 | P38646 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | RGS12 | O14924 | 1/20 | 0.39 |
| ▸ | NQO2 | P16083 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10695502 | 0.96 | MAPT (0.49) | KMT2AMEN1MAPTSMN1; SMN2THRB | |
| SCHEMBL10695610 | 0.91 | MAPT (0.51) | KMT2AMEN1MAPTSMN1; SMN2THRB | |
| SCHEMBL10708746 | 0.86 | MAPT (0.50) | KMT2AMEN1MAPTSMN1; SMN2THRB | |
| SCHEMBL10706414 | 0.83 | MAPT (0.48) | KMT2AMEN1MAPTSMN1; SMN2THRB | |
| SCHEMBL2492094 | 0.79 | MAPT (0.57) | KMT2AMEN1MAPTSMN1; SMN2THRB | |
| SCHEMBL10693959 | 0.79 | ELANE (0.50) | KMT2AMEN1MAPTSMN1; SMN2THRB | |
| SCHEMBL5546481 | 0.78 | MAPT (0.46) | KMT2AMEN1MAPTSMN1; SMN2POLB | |
| SCHEMBL5548196 | 0.77 | MAPT (0.45) | KMT2AMEN1MAPTSMN1; SMN2TP53 | |
| SCHEMBL5546476 | 0.77 | SCN9A (0.44) | KMT2AMEN1SCN9A | |
| SCHEMBL5548195 | 0.76 | SCN9A (0.43) | KMT2AMEN1SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |