Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 6/20 | 0.58 |
| ▸ | RARA | P10276 | 4/20 | 0.58 |
| ▸ | RARG | P13631 | 3/20 | 0.43 |
| ▸ | RXRA | P19793 | 5/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | RXRB | P28702 | 2/20 | 0.41 |
| ▸ | HNF4A | P41235 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | RXRG | P48443 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7669186 | 0.91 | RARB (0.50) | RARBRARARARGRXRAHDAC1 | |
| SCHEMBL9145602 | 0.88 | RARB (0.47) | RARBRARARARGRXRARXRB | |
| SCHEMBL26471787 | 0.86 | RARA (0.76) | RARBRARARARGRXRAHNF4A | |
| SCHEMBL7671024 | 0.84 | RARA (0.52) | RARBRARARARGRXRARXRB | |
| SCHEMBL7671033 | 0.84 | RARA (0.52) | RARBRARARARGRXRARXRB | |
| SCHEMBL7671029 | 0.84 | RARA (0.52) | RARBRARARARGRXRARXRB | |
| SCHEMBL10558185 | 0.84 | NOTUM (0.44) | RARBRARARARGRXRAHDAC1 | |
| SCHEMBL17325079 | 0.82 | RARA (0.53) | RARBRARAHPGD | |
| SCHEMBL7665311 | 0.82 | RARA (0.50) | RARBRARARARGRXRAHDAC1 | |
| SCHEMBL7665318 | 0.82 | RARA (0.50) | RARBRARARARGRXRAHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4788213-A | TREATING ACNE AND PSORIASIS | HOFFMAN-LA ROCHE INC. (US) | 1988-11-29 | — | — | US | disclosed |
| US-4678793-A | ACNE, PSORIASIS, ANTITUMOR | HOFFMANN-LA ROCHE INC. (US) | 1987-07-07 | — | — | US | disclosed |