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RARA

Retinoic acid receptor alpha · P10276 · RARA on Sugi Atlas →

84,781 patent compounds predicted against RARA, 43,876 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL346037 SCHEMBL346037 1.00 18/20
SCHEMBL381579 SCHEMBL381579 1.00 18/20
SCHEMBL381582 SCHEMBL381582 1.00 18/20
SCHEMBL381691 SCHEMBL381691 1.00 18/20
SCHEMBL381776 SCHEMBL381776 1.00 18/20
SCHEMBL381861 SCHEMBL381861 1.00 18/20
SCHEMBL382094 SCHEMBL382094 1.00 18/20
SCHEMBL382095 SCHEMBL382095 1.00 18/20
SCHEMBL382245 SCHEMBL382245 1.00 18/20
SCHEMBL382382 SCHEMBL382382 1.00 18/20
SCHEMBL382466 SCHEMBL382466 1.00 18/20
SCHEMBL382479 SCHEMBL382479 1.00 18/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL382480) 1.00 18/20
SCHEMBL381948 SCHEMBL381948 0.96 18/20
SCHEMBL382316 SCHEMBL382316 0.89 18/20
SCHEMBL381853 SCHEMBL381853 0.85 18/20
SCHEMBL381976 SCHEMBL381976 0.84 18/20
SCHEMBL381623 SCHEMBL381623 0.83 18/20
SCHEMBL382047 SCHEMBL382047 0.83 18/20
SCHEMBL382031 SCHEMBL382031 0.82 18/20

Clinical trials — most relevant to RARA by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Investigating the Potential Role of Aerosolized Retinoic Acid, a Potent Vitamin A Metabolite for Treating COVID-19 Anosmia and Retinoic Acid Insufficiency .A Novel Approach for Regaining Sense of Smell. PHASE4UNKNOWN
Tazarotene Plus Clindamycin vs. Adapalene Plus Clindamycin in the Treatment of Facial Acne Vulgaris PHASE4COMPLETED
Efficacy and Safety of Two Doses of Liarozole vs. Placebo for the Treatment of Lamellar Ichthyosis PHASE2/PHASE3COMPLETED
Treatment Study for Children and Adolescents With Acute Promyelocitic Leukemia PHASE3UNKNOWN
Combination Chemotherapy With or Without Bone Marrow Transplantation in Treating Patients With Acute Promyelocytic Leukemia PHASE3UNKNOWN
Comparing Two Different Myeloablation Therapies in Treating Young Patients Who Are Undergoing a Stem Cell Transplant for High-Risk Neuroblastoma PHASE3COMPLETED
Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Promyelocytic Leukemia PHASE3COMPLETED
Assessment the Activity Value of Isotretinoin (13- Cis-Retinoic Acid ) in the Treatment of COVID-19 ( Isotretinoin in Treatment of COVID-19) (Randomized) PHASE3UNKNOWN
Investigating the Role of 13cis Retinoic Acid in the Treatment of COVID-19 and Enhancement of Its Spike Protein Based Vaccine Efficacy and Safety. PHASE1/PHASE2UNKNOWN
Efficacy and Safety of Tamibarotene(AM80) for Lupus Nephritis PHASE2UNKNOWN
Feasibility of Retinoic Acid Treatment in Emphysema (FORTE) PHASE2COMPLETED
Aerosol Combination Therapy of All-trans Retinoic Acid and Isotretinoin as A Novel Treatment for Inducing Neutralizing Antibodies in COVID -19 Infected Patients Better Than Vaccine : An Innovative Treatment PHASE2UNKNOWN
Pembrolizumab and All-Trans Retinoic Acid Combination Treatment of Advanced Melanoma PHASE1/PHASE2COMPLETED
A Study of Targretin Capsules in Patients With AIDS-Related Kaposi's Sarcoma PHASE2COMPLETED
Phase II 5-Azacytidine Plus VPA Plus ATRA PHASE2COMPLETED
Lymphocyte Support to SBRT in Patients With Oligo-metastatic Solid Cancer PHASE1/PHASE2RECRUITING
Treatment of Chidamide and Venetoclax for Retinoic Acid and Arsenic Resistant Acute Promyelocytic Leukemia PHASE2RECRUITING
ATRA and Carfilzomib in Plasma Cell Myeloma Patients PHASE1/PHASE2RECRUITING
5-azacytidine Valproic Acid and ATRA in AML and High Risk MDS PHASE2COMPLETED
Daratumumab in Combination With ATRA PHASE1/PHASE2COMPLETED
All-Trans Retinoic Acid (ATRA) Plus PD-1 Inhibition in Recurrent IDH-Mutant Glioma PHASE2RECRUITING
Combination Therapy With Isotretinoin and Tamoxifen Expected to Provide Complete Protection Against Severe Acute Respiratory Syndrome Coronavirus PHASE2UNKNOWN
Treatment of Acute Myeloid Leukemia With Arsenic and All-trans Retinoid Acid PHASE1UNKNOWN
Oral Clofarabine for Acute Myeloid Leukemia PHASE1COMPLETED
A Clinical Trial Evaluating the Safety and Efficacy of Intravenous CD-801 in Treating Advanced HCC Patients EARLY_PHASE1RECRUITING
A Clinical Trial for the Safety and Efficacy of CD-801 in Patients With Advanced Hepatocellular Carcinoma EARLY_PHASE1COMPLETED
Prevalence Of Vitamin A Deficiency In Critically Ill Children With Sepsis And Its Association With Clinical Outcomes nanCOMPLETED
Retinoic Acid Homeostasis in Neuropsychiatric Diseases nanUNKNOWN
Vitamin A Supplementation in Preterm Infants nanUNKNOWN
RORC Genetic Polymorphism of Rheumatoid Arthritis nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a RARA binder may also engage these)

ProteinNameSimilarity
P11416 — 1.000 P11416 →
P18514 — 1.000 P18514 →
Q5FBR4 — 1.000 Q5FBR4 →
Q9W5Z3 — 1.000 Q9W5Z3 →
Q9W6B3 — 1.000 Q9W6B3 →
Q90966 — 1.000 Q90966 →
RARB Retinoic acid receptor beta 1.000 landscape →
P22448 — 0.999 P22448 →
P22605 — 0.999 P22605 →
Q7ZTI3 — 0.998 Q7ZTI3 →
P51126 — 0.998 P51126 →
Q90271 — 0.997 Q90271 →
P28699 — 0.993 P28699 →
Q91392 — 0.992 Q91392 →
P18911 — 0.991 P18911 →
RARG Retinoic acid receptor gamma 0.990 landscape →
A2T928 — 0.986 A2T928 →
P18516 — 0.984 P18516 →
PI4KB Phosphatidylinositol 4-kinase beta 0.973 landscape →
Q641K1 — 0.973 Q641K1 →
B1MTG7 — 0.971 B1MTG7 →
Q69ZT9 — 0.971 Q69ZT9 →
Q6NRE7 — 0.971 Q6NRE7 →
F1R7R1 — 0.971 F1R7R1 →
B2KI64 — 0.970 B2KI64 →
Q9UPW5 — 0.970 Q9UPW5 →
Q99MU3 — 0.970 Q99MU3 →
O02810 — 0.970 O02810 →
B0KWC1 — 0.969 B0KWC1 →
A4IID4 — 0.969 A4IID4 →