SCHEMBL10694952

SCHEMBL10694952

COc1cc(C(=O)c2ccccc2)c(C(=O)O)cc1N(C)C

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 7/20 0.51
MAPT P10636 6/20 0.51
KDM4E B2RXH2 5/20 0.51
HPGD P15428 5/20 0.51
HSD17B10 Q99714 2/20 0.51
CYP3A4 P08684 2/20 0.51
RECQL P46063 1/20 0.51
MAPK1 P28482 2/20 0.49
ALOX15 P16050 1/20 0.49
KMT2A Q03164 3/20 0.46
GFER P55789 1/20 0.46
HTT P42858 4/20 0.46
NPSR1 Q6W5P4 2/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
ALDH1A1 P00352 4/20 0.45
POLB P06746 2/20 0.45
AKR1C3 P42330 1/20 0.45
CYP1A2 P05177 3/20 0.44
CYP2C19 P33261 3/20 0.44
CYP2D6 P10635 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8557481 0.86 KDM4E (0.61) LMNAMAPTKDM4EHPGDHSD17B10
SCHEMBL7438219 0.81 MAPT (0.67) LMNAMAPTKDM4EHPGDHSD17B10
SCHEMBL12082118 0.81 MAPT (0.77) LMNAMAPTKDM4EHPGDHSD17B10
SCHEMBL10697549 0.81 KDM4E (0.50) LMNAMAPTKDM4EHPGDHSD17B10
SCHEMBL10691453 0.79 KDM4E (0.49) LMNAMAPTKDM4EHPGDHSD17B10
SCHEMBL28729593 0.78 HPGD (0.63) LMNAMAPTKDM4EHPGDHSD17B10
SCHEMBL27939608 0.76 MAPT (0.76) LMNAMAPTKDM4EHPGDHSD17B10
SCHEMBL10695457 0.75 KDM4E (0.67) LMNAMAPTKDM4EHPGDMAPK1
SCHEMBL1656198 0.75 ATM (0.60) HPGDSMN1; SMN2NPC1RAB9A
SCHEMBL4543074 0.75 MAPT (0.63) LMNAMAPTKDM4EHPGDHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4748148-A Recording system utilizing phthalide derivatives as colorless chromogenic material NEW OJI PAPER CO., LTD. (JP) 1988-05-31 US disclosed
US-4641160-A Recording system utilizing phthalide derivatives as colorless chromogenic material KANZAKI PAPER MANUFACTURING CO., LTD. (JP) 1987-02-03 US disclosed
EP-0127203-A1 New phthalide derivatives, process for preparing the same and recording system utilizing the same as colourless chromogenic material KANZAKI PAPER MANUFACTURING CO., LTD (JP) 1984-12-05 EP disclosed
EP-0062544-A1 New phthalide derivatives, process for preparing the same and recording system utilizing the same as colourless chromogenic material KANZAKI PAPER MANUFACTURING COMPANY LIMITED (JP) 1982-10-13 EP disclosed