Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | F2 | P00734 | 2/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.53 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.53 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10694055 | 0.84 | NAMPT (0.59) | NAMPTHDAC2HDAC1HDAC3HDAC4 | |
| SCHEMBL10696004 | 0.84 | NAMPT (0.59) | NAMPTMAPTHDAC2HDAC1HDAC3 | |
| Hydrochloric Acid SCHEMBL10695546 | 0.83 | HDAC1 (0.65) | NAMPTPOLBHDAC2HDAC1HDAC11 | |
| SCHEMBL10696975 | 0.82 | POLB (0.59) | POLBHDAC2HDAC1HDAC3HDAC4 | |
| Hydrochloric Acid SCHEMBL10694072 | 0.82 | TSHR (0.58) | HPGDPOLBMAPTHDAC2HDAC1 | |
| Hydrochloric Acid SCHEMBL10696995 | 0.81 | KDM4E (0.63) | HPGDPOLBMAPTHDAC2HDAC1 | |
| SCHEMBL10644987 | 0.81 | NAMPT (0.58) | NAMPTHPGDMAPTF2HDAC2 | |
| Hydrochloric Acid SCHEMBL10606782 | 0.80 | F2 (0.57) | NAMPTHPGDMAPTF2HDAC2 | |
| SCHEMBL9055150 | 0.80 | HPGD (0.89) | HPGDPOLBMAPTHDAC1HDAC8 | |
| SCHEMBL24892110 | 0.79 | KMT2A (0.56) | NAMPTPOLBMAPTF2HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268267-A2 | Guanidinomethylbenzoic acid derivatives, compositions containing the same, processes for preparing the same, and the use of the same in the manufacture of medicaments of therapeutic value | NIPPON HYPOX LABORATORIES INCORPORATED (JP) | 1988-05-25 | — | — | EP | disclosed |