Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 3/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.48 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | TSSK1B | Q9BXA7 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 5/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10701072 | 0.90 | AURKA (0.59) | AURKAAURKBPDE4APDE4BPDE4C | |
| SCHEMBL10698460 | 0.86 | AURKA (0.48) | AURKAAURKBPDE4APDE4BPDE4C | |
| SCHEMBL10695107 | 0.86 | AURKA (0.46) | AURKAAURKBPDE4APDE4BPDE4C | |
| SCHEMBL10693690 | 0.84 | PDE4A (0.51) | AURKAAURKBPDE4APDE4BPDE4C | |
| SCHEMBL10695197 | 0.82 | AURKA (0.46) | AURKAAURKBPDE4APDE4BPDE4C | |
| SCHEMBL10695207 | 0.82 | AURKB (0.46) | AURKAAURKBPDE4APDE4BPDE4C | |
| SCHEMBL10696394 | 0.81 | PDE4A (0.52) | AURKAAURKBPDE4APDE4BPDE4C | |
| SCHEMBL13368132 | 0.81 | AURKA (0.53) | AURKAAURKBPDE4APDE4BPDE4C | |
| SCHEMBL10695285 | 0.81 | AURKA (0.47) | AURKAAURKB | |
| SCHEMBL13341481 | 0.81 | AURKA (0.45) | AURKAAURKBPDE3BPDE3AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |