Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CBFB | Q13951 | 11/20 | 0.54 |
| ▸ | METAP2 | P50579 | 7/20 | 0.54 |
| ▸ | METAP1 | P53582 | 6/20 | 0.54 |
| ▸ | NPC1 | O15118 | 7/20 | 0.53 |
| ▸ | RAB9A | P51151 | 7/20 | 0.53 |
| ▸ | PKM | P14618 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MTOR | P42345 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10698880 | 0.86 | CBFB (0.51) | CBFBMETAP2METAP1NPC1RAB9A | |
| SCHEMBL10700922 | 0.86 | CBFB (0.52) | CBFBMETAP2METAP1NPC1RAB9A | |
| SCHEMBL10699247 | 0.84 | CBFB (0.47) | CBFBMETAP2METAP1NPC1RAB9A | |
| SCHEMBL5619650 | 0.81 | AURKA (0.32) | CBFBMETAP2METAP1NPC1RAB9A | |
| SCHEMBL10694143 | 0.81 | ALDH1A1 (0.48) | NPC1RAB9AKDM4EMAPTHPGD | |
| SCHEMBL10532329 | 0.80 | CBFB (0.51) | CBFBMETAP2METAP1NPC1RAB9A | |
| SCHEMBL10695474 | 0.79 | MAPT (0.54) | NPC1RAB9ASMN1; SMN2KDM4EMAPT | |
| SCHEMBL10696182 | 0.77 | SCD (0.46) | SMN1; SMN2HPGDALDH1A1HSD17B10 | |
| SCHEMBL10695565 | 0.76 | CBFB (0.55) | CBFBMETAP2METAP1NPC1RAB9A | |
| SCHEMBL10695132 | 0.76 | CBFB (0.54) | CBFBMETAP2METAP1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |