Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | ABCC9 | O60706 | 11/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.34 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.33 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.33 |
| ▸ | KCNJ8 | Q15842 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8077234 | 0.83 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DABCC9 | |
| SCHEMBL7269375 | 0.82 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DABCC9 | |
| SCHEMBL7275951 | 0.82 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DABCC9 | |
| SCHEMBL7267833 | 0.81 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DABCC9 | |
| SCHEMBL10694946 | 0.80 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DABCC9 | |
| SCHEMBL9779699 | 0.80 | ABCC9 (0.37) | ABCC9ABCB1GABRA1GABRG2GABRB3 | |
| SCHEMBL8077075 | 0.80 | ABCC9 (0.35) | ABCC9ABCB1GABRA1GABRG2GABRB3 | |
| SCHEMBL8084447 | 0.79 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DABCC9 | |
| Bimakalim SCHEMBL231904 | 0.79 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4DABCC9 | |
| SCHEMBL8085075 | 0.78 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DABCC9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0273262-A2 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1988-07-06 | — | — | EP | disclosed |