Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | ATM | Q13315 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | RAD52 | P43351 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | BAX | Q07812 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21757993 | 1.00 | MAPT (0.61) | MAPTATMSMN1; SMN2RAD52ADRA2A | |
| SCHEMBL14034485 | 1.00 | MAPT (0.61) | MAPTATMSMN1; SMN2RAD52ADRA2A | |
| SCHEMBL4400918 | 0.98 | MAPT (0.64) | MAPTATMSMN1; SMN2RAD52ADRA2A | |
| SCHEMBL16908299 | 0.98 | MAPT (0.64) | MAPTATMSMN1; SMN2RAD52ADRA2A | |
| SCHEMBL1361161 | 0.98 | MAPT (0.64) | MAPTATMSMN1; SMN2RAD52ADRA2A | |
| SCHEMBL15553304 | 0.96 | MAPT (0.61) | MAPTATMSMN1; SMN2RAD52ADRA2A | |
| SCHEMBL9493787 | 0.90 | MAPT (0.67) | MAPTATMSMN1; SMN2RAD52ADRA2A | |
| SCHEMBL151400 | 0.89 | SMN1; SMN2 (0.58) | MAPTATMSMN1; SMN2RAD52BAX | |
| SCHEMBL11438133 | 0.86 | SMN1; SMN2 (0.60) | MAPTATMSMN1; SMN2RAD52BAX | |
| SCHEMBL9059747 | 0.85 | MAPT (0.54) | MAPTATMSMN1; SMN2RAD52ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0255471-A1 | 1,4,7,10-Tetraazacyclododecane-derivatives | SCHERING AKTIENGESELLSCHAFT (DE) | 1988-02-03 | — | — | EP | claimed |