Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.67 |
| ▸ | ATM | Q13315 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | CXCR4 | P61073 | 7/20 | 0.46 |
| ▸ | RAD52 | P43351 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CCR2 | P41597 | 1/20 | 0.41 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | BAX | Q07812 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4400918 | 0.92 | MAPT (0.64) | MAPTATMSMN1; SMN2MEN1KMT2A | |
| SCHEMBL16908299 | 0.92 | MAPT (0.64) | MAPTATMSMN1; SMN2MEN1KMT2A | |
| SCHEMBL1361161 | 0.92 | MAPT (0.64) | MAPTATMSMN1; SMN2MEN1KMT2A | |
| SCHEMBL14034485 | 0.90 | MAPT (0.61) | MAPTATMSMN1; SMN2MEN1KMT2A | |
| SCHEMBL10696876 | 0.90 | MAPT (0.61) | MAPTATMSMN1; SMN2MEN1KMT2A | |
| SCHEMBL15553304 | 0.90 | MAPT (0.61) | MAPTATMSMN1; SMN2MEN1KMT2A | |
| SCHEMBL21757993 | 0.90 | MAPT (0.61) | MAPTATMSMN1; SMN2MEN1KMT2A | |
| Piperidine SCHEMBL4181536 | 0.89 | ATM (0.73) | MAPTATMSMN1; SMN2MEN1KMT2A | |
| SCHEMBL20307045 | 0.86 | MEN1 (0.68) | MAPTATMSMN1; SMN2MEN1KMT2A | |
| SCHEMBL7575576 | 0.83 | SMN1; SMN2 (0.47) | MAPTATMSMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0230402-B1 | PHARMACOLOGICALLY ACTIVE ALKYLOL DERIVATIVES | DOMPE' FARMACEUTICI S.p.A. (IT) | 1993-04-21 | — | — | EP | disclosed |
| US-4849422-A | PIPERAZINE-SUBSTITUTED, ANTITUSSIVE | DOMPE' FARMACEUTICI S.P.A. (IT) | 1989-07-18 | — | — | US | disclosed |
| EP-0230402-A2 | Pharmacologically active alkylol derivatives | DOMPE' FARMACEUTICI S.p.A. (IT) | 1987-07-29 | — | — | EP | disclosed |