Quinoline

Quinoline

SCHEMBL10696880

Cc1ccc2ccccc2c1C=O.c1ccc2ncccc2c1

nearest known ligand 0.50

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.50
CYP3A4 P08684 1/20 0.47
L3MBTL1 Q9Y468 2/20 0.46
GAA P10253 1/20 0.46
TDP1 Q9NUW8 1/20 0.46
MAPT P10636 2/20 0.46
CYP1A2 P05177 1/20 0.46
CYP2C9 P11712 1/20 0.46
CYP2C19 P33261 1/20 0.46
ERN1 O75460 5/20 0.45
CCR1 P32246 1/20 0.44
CCR8 P51685 1/20 0.44
ADRB2 P07550 1/20 0.44
ADRB1 P08588 1/20 0.44
SMN1; SMN2 Q16637 2/20 0.43
NPC1 O15118 1/20 0.43
RAB9A P51151 1/20 0.43
LMNA P02545 3/20 0.42
CYP2A6 P11509 1/20 0.41
SLC40A1 Q9NP59 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL230035 0.84 ERN1 (0.60) ALDH1A1L3MBTL1GAATDP1MAPT
SCHEMBL29357470 0.84 ERN1 (0.60) ALDH1A1L3MBTL1GAATDP1MAPT
SCHEMBL29377043 0.82 ERN1 (0.58) ALDH1A1L3MBTL1GAATDP1MAPT
SCHEMBL20562670 0.81 ERN1 (0.65) ALDH1A1CYP3A4L3MBTL1MAPTCYP1A2
Quinoline SCHEMBL8846098 0.78 ALDH1A1 (0.45) ALDH1A1CYP3A4L3MBTL1GAATDP1
SCHEMBL20669627 0.78 ERN1 (0.65) ALDH1A1CYP3A4L3MBTL1GAATDP1
Quinoline SCHEMBL16047322 0.77 ALDH1A1 (0.55) ALDH1A1CYP3A4L3MBTL1MAPTCYP1A2
Phenanthrene SCHEMBL28062390 0.77 ALDH1A1 (0.77) ALDH1A1CYP3A4TDP1MAPTCYP1A2
SCHEMBL15845323 0.76 HPRT1 (0.52) ALDH1A1CYP3A4L3MBTL1GAATDP1
Quinoline SCHEMBL28269722 0.76 ALDH1A1 (0.63) ALDH1A1CYP3A4L3MBTL1MAPTCYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0278543-A1 Process and composition for inhibiting high-temperature iron and steel corrosion PUMPTECH N.V. (BE) 1988-08-17 EP disclosed