SCHEMBL10697484

SCHEMBL10697484

CNC(=O)Oc1ccc(-c2noc(C(F)(F)F)n2)cc1

nearest known ligand 0.68

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
HDAC4 P56524 19/20 0.68
HDAC6 Q9UBN7 10/20 0.68
HDAC1 Q13547 2/20 0.60
HDAC8 Q9BY41 1/20 0.60
HDAC5 Q9UQL6 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10558210 0.86 HDAC4 (0.74) HDAC4HDAC6HDAC1HDAC8HDAC5
SCHEMBL10552122 0.86 HDAC4 (0.70) HDAC4HDAC6HDAC1HDAC8HDAC5
SCHEMBL28702951 0.83 HDAC4 (0.58) HDAC4HDAC6HDAC1HDAC8
SCHEMBL20594106 0.82 HDAC4 (0.65) HDAC4HDAC6HDAC1HDAC8HDAC5
SCHEMBL21462401 0.82 HDAC4 (0.68) HDAC4HDAC6HDAC1HDAC8HDAC5
SCHEMBL21543860 0.81 HDAC6 (0.72) HDAC4HDAC6HDAC1HDAC8HDAC5
SCHEMBL14645806 0.81 HDAC4 (1.00) HDAC4HDAC6HDAC1
SCHEMBL10553943 0.81 HDAC4 (0.54) HDAC4HDAC6HDAC1HDAC8HDAC5
SCHEMBL10559354 0.81 HDAC4 (0.67) HDAC4HDAC6HDAC1HDAC8HDAC5
SCHEMBL21175490 0.79 HDAC4 (0.76) HDAC4HDAC6HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0276432-A2 Pesticides CIBA-GEIGY AG (CH) 1988-08-03 EP claimed
EP-0276432-A2 Pesticides CIBA-GEIGY AG (CH) 1988-08-03 EP disclosed