Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10700455 | 0.96 | HDAC1 (0.42) | HDAC1HDAC8BRD4PARP1ALDH1A1 | |
| SCHEMBL10699602 | 0.90 | KDM4E (0.45) | BRD4PARP1ALDH1A1LMNACHEK2 | |
| SCHEMBL10697218 | 0.90 | BRD4 (0.49) | BRD4PARP1ALDH1A1LMNACHEK2 | |
| SCHEMBL10700736 | 0.89 | BRD4 (0.41) | HDAC1HDAC8BRD4ALDH1A1CHEK2 | |
| SCHEMBL10698666 | 0.87 | MEN1 (0.41) | HDAC1HDAC8BRD4ALDH1A1LMNA | |
| SCHEMBL10700863 | 0.86 | BRD4 (0.45) | BRD4PARP1ALDH1A1LMNACHEK2 | |
| SCHEMBL10709508 | 0.85 | DHODH (0.41) | HDAC1HDAC8BRD4ALDH1A1CHEK2 | |
| SCHEMBL10700878 | 0.81 | POLB (0.40) | BRD4PARP1ALDH1A1LMNACHEK2 | |
| SCHEMBL10697806 | 0.79 | BRD4 (0.50) | HDAC1HDAC8BRD4ALDH1A1CHEK2 | |
| SCHEMBL10700220 | 0.79 | SLC2A1 (0.46) | PARP1ALDH1A1LMNACHEK2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |