Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | TGM2 | P21980 | 1/20 | 0.36 |
| ▸ | TGM1 | P22735 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | TGM3 | Q08188 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10700863 | 0.96 | BRD4 (0.45) | BRD4LMNATSHRNPSR1AURKA | |
| SCHEMBL10699602 | 0.90 | KDM4E (0.45) | BRD4LMNATSHRNPSR1KDM4E | |
| SCHEMBL10697520 | 0.90 | HDAC1 (0.42) | BRD4LMNATSHRNPSR1KDM4E | |
| SCHEMBL10697806 | 0.87 | BRD4 (0.50) | BRD4AURKAAURKBALDH1A1RAB9A | |
| SCHEMBL10699166 | 0.86 | BRD4 (0.51) | BRD4LMNAAURKAAURKBKDM4E | |
| SCHEMBL10700455 | 0.86 | HDAC1 (0.42) | BRD4LMNATSHRNPSR1KDM4E | |
| SCHEMBL10698656 | 0.83 | BRD4 (0.46) | BRD4AURKAAURKBALDH1A1RAB9A | |
| SCHEMBL10700878 | 0.83 | POLB (0.40) | BRD4LMNATSHRNPSR1KDM4E | |
| SCHEMBL10699071 | 0.80 | BRD4 (0.50) | BRD4AURKAAURKBMAPTMEN1 | |
| SCHEMBL10698669 | 0.78 | BRD4 (0.40) | BRD4LMNAAURKAAURKBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |