Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | MGAM | O43451 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | SI | P14410 | 1/20 | 0.32 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.32 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9667048 | 0.83 | TSHR (0.48) | TSHRLMNAKDM4EALDH1A1KMT2A | |
| SCHEMBL392424 | 0.78 | CES2 (0.46) | TSHRALDH1A1ELANE | |
| SCHEMBL9543 | 0.77 | TSHR (0.68) | TSHRLMNAKDM4EALDH1A1KMT2A | |
| SCHEMBL9666382 | 0.76 | TSHR (0.54) | TSHRLMNAKDM4EALDH1A1KMT2A | |
| SCHEMBL8736205 | 0.74 | ELANE (0.32) | ALDH1A1ELANE | |
| SCHEMBL8733360 | 0.74 | CES1 (0.50) | ALDH1A1ELANE | |
| SCHEMBL15635179 | 0.72 | TSHR (0.54) | TSHRLMNAKDM4EALDH1A1KMT2A | |
| Dimethyl Succinate SCHEMBL28054469 | 0.71 | TSHR (1.00) | TSHRLMNAKDM4EALDH1A1KMT2A | |
| Dimethyl Succinate SCHEMBL10213 | 0.71 | TSHR (1.00) | TSHRLMNAKDM4EALDH1A1KMT2A | |
| SCHEMBL13908768 | 0.70 | TSHR (0.65) | TSHRLMNAKDM4EALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0266182-A2 | Gamma-lactonecarboxylic acid derivatives and their production | Takeda Chemical Industries, Ltd. (JP) | 1988-05-04 | — | — | EP | disclosed |