Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CBFB | Q13951 | 13/20 | 0.47 |
| ▸ | METAP2 | P50579 | 5/20 | 0.47 |
| ▸ | METAP1 | P53582 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | GCK | P35557 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10700944 | 0.87 | CBFB (0.54) | CBFBMETAP2METAP1NPC1RAB9A | |
| SCHEMBL10695565 | 0.84 | CBFB (0.55) | CBFBMETAP2METAP1NPC1RAB9A | |
| SCHEMBL10530411 | 0.83 | CBFB (0.47) | CBFBMETAP2METAP1NPC1RAB9A | |
| SCHEMBL10699532 | 0.80 | SLC2A1 (0.47) | NPC1RAB9APKMKDM4ELMNA | |
| SCHEMBL10697404 | 0.80 | TOP1 (0.44) | KDM4ESMN1; SMN2 | |
| SCHEMBL10700908 | 0.80 | AURKA (0.50) | CBFBMETAP2METAP1NPC1RAB9A | |
| SCHEMBL10699247 | 0.80 | CBFB (0.47) | CBFBMETAP2METAP1NPC1RAB9A | |
| SCHEMBL10699776 | 0.80 | CA12 (0.44) | NPC1RAB9AKDM4EKMT2A | |
| SCHEMBL10530503 | 0.77 | CBFB (0.46) | CBFBMETAP2METAP1NPC1RAB9A | |
| SCHEMBL10531412 | 0.77 | CBFB (0.46) | CBFBMETAP2METAP1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |