Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 2/20 | 0.44 |
| ▸ | TOP2A | P11388 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.42 |
| ▸ | BMPR1A | P36894 | 2/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.42 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.42 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.42 |
| ▸ | SCD | O00767 | 1/20 | 0.40 |
| ▸ | RHEB | Q15382 | 1/20 | 0.40 |
| ▸ | GUSB | P08236 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | CTSC | P53634 | 2/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10699532 | 0.90 | SLC2A1 (0.47) | ALDH1A1HPGDSMN1; SMN2HSD17B10BMPR1B | |
| SCHEMBL10699429 | 0.89 | TOP1 (0.45) | TOP1TOP2AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL10698699 | 0.88 | TOP1 (0.44) | TOP1TOP2AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL10532544 | 0.82 | TOP1 (0.42) | TOP1TOP2AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL10697614 | 0.80 | CBFB (0.47) | SMN1; SMN2KDM4E | |
| SCHEMBL10698967 | 0.79 | AURKB (0.47) | TOP1TOP2AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL10698622 | 0.79 | SCD (0.40) | TOP1TOP2AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL10700889 | 0.78 | BMPR1B (0.43) | ALDH1A1HPGDSMN1; SMN2BMPR1BBMPR1A | |
| SCHEMBL10698172 | 0.77 | RHEB (0.49) | ALDH1A1HPGDHSD17B10BMPR1BBMPR1A | |
| SCHEMBL10530438 | 0.76 | GUSB (0.40) | TOP1TOP2AALDH1A1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |