Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | KDM5A | P29375 | 3/20 | 0.42 |
| ▸ | PHF8 | Q9UPP1 | 3/20 | 0.42 |
| ▸ | KDM2A | Q9Y2K7 | 3/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.42 |
| ▸ | KDM4A | O75164 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | METAP1 | P53582 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL8083985 | 0.92 | SIGMAR1 (0.77) | SIGMAR1CYP1A2KDM5APHF8KDM2A | |
| SCHEMBL10451694 | 0.87 | SIGMAR1 (0.81) | SIGMAR1CYP1A2METAP1 | |
| SCHEMBL20821278 | 0.87 | SIGMAR1 (0.81) | SIGMAR1CYP1A2METAP1 | |
| SCHEMBL128981 | 0.87 | SIGMAR1 (0.81) | SIGMAR1CYP1A2METAP1 | |
| SCHEMBL18823182 | 0.87 | SIGMAR1 (0.81) | SIGMAR1CYP1A2METAP1 | |
| SCHEMBL24733023 | 0.87 | SIGMAR1 (0.81) | SIGMAR1CYP1A2METAP1 | |
| SCHEMBL18430894 | 0.87 | SIGMAR1 (0.81) | SIGMAR1CYP1A2METAP1 | |
| SCHEMBL21944186 | 0.87 | SIGMAR1 (0.81) | SIGMAR1CYP1A2METAP1 | |
| SCHEMBL8392554 | 0.87 | SIGMAR1 (0.81) | SIGMAR1CYP1A2METAP1 | |
| Hydrochloric Acid SCHEMBL1356286 | 0.84 | SIGMAR1 (0.77) | SIGMAR1CYP1A2METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1019113-B | Process for preparing 3-arylhydrido-3-substituted propanamines | LILLY CO ELI (US) | 1992-11-18 | — | — | CN | disclosed |
| EP-0273658-A1 | 3-Aryloxy-3-substituted propanamines | ELI LILLY AND COMPANY (US) | 1988-07-06 | — | — | EP | disclosed |
| CN-87108175-A | The propylamine that 3-aryloxy-3-replaces | — | 1988-07-06 | — | — | CN | disclosed |