Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.47 |
| ▸ | MAOA | P21397 | 2/20 | 0.47 |
| ▸ | MAOB | P27338 | 2/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.47 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.47 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.46 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.46 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.46 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.46 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.46 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22874558 | 0.86 | POLB (0.53) | POLBKDM4EADRA2AMAOAMAOB | |
| SCHEMBL3646089 | 0.84 | KMT2A (0.54) | POLBKDM4EADRA2ASLC6A3BRD4 | |
| SCHEMBL22874530 | 0.83 | POLB (0.43) | POLBKDM4EADRA2ASLC6A3SLC6A2 | |
| SCHEMBL22874531 | 0.82 | TDP1 (0.43) | POLBKDM4EADRA2ASLC6A3GABRA1 | |
| SCHEMBL27967202 | 0.82 | BRD4 (0.44) | POLBKDM4EADRA2ASLC6A3SLC6A4 | |
| SCHEMBL27967203 | 0.82 | BRD4 (0.44) | POLBKDM4EADRA2ASLC6A3SLC6A4 | |
| SCHEMBL10656947 | 0.80 | SLC6A2 (0.50) | POLBKDM4EADRA2ASLC6A3SLC6A2 | |
| SCHEMBL23405959 | 0.80 | TRPM8 (0.48) | POLBKDM4EBRD4CREBBPSMN1; SMN2 | |
| SCHEMBL29743964 | 0.80 | TRPM8 (0.48) | POLBKDM4EBRD4CREBBPSMN1; SMN2 | |
| SCHEMBL3646066 | 0.80 | BRD4 (0.45) | POLBKDM4EADRA2ASLC6A3BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0279707-A2 | Aryloxymethyl derivatives of nitrogenous heterocyclic methanols and ethers thereof having cardiovascular activity | A.H. ROBINS COMPANY, INCORPORATED (US) | 1988-08-24 | — | — | EP | claimed |
| US-9206128-B2 | Modulators of methyl modifying enzymes, compositions and uses thereof | CONSTELLATION PHARMACEUTICALS, INC. (US) | 2015-12-08 | — | — | US | disclosed |