Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 5/20 | 0.39 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4116188 | 1.00 | TP53 (0.43) | TP53SIRT2SYKKDM4EMAPT | |
| SCHEMBL4712834 | 1.00 | TP53 (0.43) | TP53SIRT2SYKKDM4EMAPT | |
| Fumaric Acid SCHEMBL10698822 | 0.91 | KDM4E (0.44) | TP53SIRT2SYKKDM4EMAPT | |
| Maleic Acid SCHEMBL10698810 | 0.91 | KDM4E (0.44) | TP53SIRT2SYKKDM4EMAPT | |
| SCHEMBL30646221 | 0.85 | KDM4E (0.47) | TP53SIRT2KDM4EMAPTALDH1A1 | |
| SCHEMBL30359443 | 0.83 | TP53 (0.43) | TP53SIRT2KDM4EMAPTALDH1A1 | |
| SCHEMBL29977959 | 0.81 | PARP1 (0.43) | TP53SIRT2KDM4EMAPTALDH1A1 | |
| SCHEMBL161226 | 0.80 | KDM4E (0.50) | TP53SIRT2KDM4EMAPTALDH1A1 | |
| SCHEMBL307050 | 0.79 | KDM4E (0.53) | TP53SIRT2KDM4EMAPTALDH1A1 | |
| SCHEMBL10833645 | 0.78 | KDM1A (0.34) | KDM4ETSHRHSD17B10MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0263208-A2 | Antiarrhythmic use of aminocycloalkylamides | THE UPJOHN COMPANY (US) | 1988-04-13 | — | — | EP | claimed |
| EP-0263208-A2 | Antiarrhythmic use of aminocycloalkylamides | THE UPJOHN COMPANY (US) | 1988-04-13 | — | — | EP | disclosed |