Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 6/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL10698822 | 1.00 | KDM4E (0.44) | KDM4EALDH1A1HPGDPOLBMEN1 | |
| SCHEMBL10697894 | 0.91 | TP53 (0.43) | KDM4EALDH1A1HPGDPOLBMEN1 | |
| SCHEMBL4116188 | 0.91 | TP53 (0.43) | KDM4EALDH1A1HPGDPOLBMEN1 | |
| SCHEMBL4712834 | 0.91 | TP53 (0.43) | KDM4EALDH1A1HPGDPOLBMEN1 | |
| SCHEMBL28037676 | 0.88 | KDM4E (0.41) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL30646221 | 0.78 | KDM4E (0.47) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL30359443 | 0.75 | TP53 (0.43) | KDM4EALDH1A1HPGDPOLBMEN1 | |
| SCHEMBL29977959 | 0.74 | PARP1 (0.43) | KDM4EALDH1A1HPGDTP53SIRT2 | |
| SCHEMBL161226 | 0.73 | KDM4E (0.50) | KDM4EALDH1A1HPGDPOLBMEN1 | |
| SCHEMBL307050 | 0.72 | KDM4E (0.53) | KDM4EALDH1A1HPGDPOLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0263208-A2 | Antiarrhythmic use of aminocycloalkylamides | THE UPJOHN COMPANY (US) | 1988-04-13 | — | — | EP | claimed |