Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | KDM4A | O75164 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | HSPA9 | P38646 | 4/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MYC | P01106 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4512009 | 0.83 | MEN1 (0.44) | MEN1KMT2ASMN1; SMN2POLBMAPT | |
| SCHEMBL2492094 | 0.82 | MAPT (0.57) | MEN1KMT2ASMN1; SMN2POLBMAPT | |
| SCHEMBL10882762 | 0.79 | MEN1 (0.48) | MEN1KMT2ASMN1; SMN2POLBMAPT | |
| SCHEMBL10708746 | 0.78 | MAPT (0.50) | MEN1KMT2ASMN1; SMN2POLBMAPT | |
| SCHEMBL10883259 | 0.78 | POLB (0.47) | MEN1KMT2ASMN1; SMN2POLBMAPT | |
| SCHEMBL10695610 | 0.76 | MAPT (0.51) | MEN1KMT2ASMN1; SMN2POLBMAPT | |
| SCHEMBL10883793 | 0.75 | SMN1; SMN2 (0.44) | MEN1KMT2ASMN1; SMN2POLBMAPT | |
| SCHEMBL5541399 | 0.75 | MEN1 (0.49) | MEN1KMT2ASMN1; SMN2POLBMAPT | |
| SCHEMBL10695502 | 0.74 | MAPT (0.49) | MEN1KMT2ASMN1; SMN2POLBMAPT | |
| SCHEMBL5010350 | 0.74 | ALDH1A1 (0.39) | MEN1KMT2ASMN1; SMN2GLAHSPA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |