Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 4/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 8/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | G6PD | P11413 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10707934 | 0.89 | CYP11B1 (0.47) | CYP11B1CYP11B2NAMPTKITMEN1 | |
| SCHEMBL10700226 | 0.88 | MEN1 (0.41) | KITMEN1KMT2ABRD4ATM | |
| SCHEMBL10699071 | 0.85 | BRD4 (0.50) | CYP11B1CYP11B2NAMPTKITMEN1 | |
| SCHEMBL10698669 | 0.85 | BRD4 (0.40) | KITMEN1KMT2ABRD4ATM | |
| SCHEMBL10697337 | 0.83 | BRD4 (0.37) | MEN1KMT2ABRD4ALDH1A1HPGD | |
| SCHEMBL10698809 | 0.81 | CYP11B1 (0.53) | CYP11B1CYP11B2NAMPTKITMEN1 | |
| SCHEMBL10699602 | 0.80 | KDM4E (0.45) | MEN1KMT2ABRD4ALDH1A1HPGD | |
| SCHEMBL10698273 | 0.79 | MAPT (0.47) | CYP11B1KITKMT2AALDH1A1HPGD | |
| SCHEMBL10699164 | 0.79 | CYP11B1 (0.47) | CYP11B1CYP11B2NAMPTKITMEN1 | |
| SCHEMBL10699542 | 0.79 | CYP11B1 (0.47) | CYP11B1CYP11B2NAMPTKITATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |