Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 5/20 | 0.53 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.53 |
| ▸ | KIT | P10721 | 7/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.39 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10699071 | 0.87 | BRD4 (0.50) | CYP11B1CYP11B2KITNAMPTATM | |
| SCHEMBL10695172 | 0.86 | MEN1 (0.47) | CYP11B1CYP11B2ATMMEN1KMT2A | |
| SCHEMBL10695690 | 0.81 | MEN1 (0.47) | CYP11B1CYP11B2ATMMEN1KMT2A | |
| SCHEMBL10707934 | 0.81 | CYP11B1 (0.47) | CYP11B1CYP11B2KITNAMPTATM | |
| SCHEMBL10698607 | 0.81 | CYP11B1 (0.47) | CYP11B1CYP11B2KITNAMPTATM | |
| SCHEMBL10697084 | 0.81 | MEN1 (0.40) | MEN1KMT2A | |
| SCHEMBL10696700 | 0.79 | CA12 (0.50) | MEN1KMT2AHTTBACE1 | |
| SCHEMBL10691668 | 0.77 | MAPT (0.54) | CYP11B1KITKMT2AHTT | |
| SCHEMBL10694299 | 0.76 | CYP11B1 (0.54) | CYP11B1CYP11B2KITNAMPTATM | |
| SCHEMBL16321891 | 0.76 | CYP11B1 (0.52) | CYP11B1CYP11B2BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |