Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | NOS1 | P29475 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 5/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.39 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.39 |
| ▸ | ABL2 | P42684 | 1/20 | 0.39 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.39 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL10698955 | 1.00 | MAPT (0.50) | MAPTKDM4ECYP3A4LMNANOS1 | |
| SCHEMBL31615135 | 0.98 | MAPT (0.52) | MAPTKDM4ECYP3A4LMNANOS1 | |
| SCHEMBL2046958 | 0.98 | MAPT (0.52) | MAPTKDM4ECYP3A4LMNANOS1 | |
| Bromide SCHEMBL10699150 | 0.97 | MAPT (0.50) | MAPTKDM4ECYP3A4LMNANOS1 | |
| Bromide SCHEMBL10699155 | 0.97 | MAPT (0.50) | MAPTKDM4ECYP3A4LMNANOS1 | |
| SCHEMBL13166541 | 0.85 | CYP3A4 (0.46) | MAPTKDM4ECYP3A4LMNANOS1 | |
| SCHEMBL325731 | 0.77 | KDM4E (0.53) | KDM4ENOS1HSP90AA1TGFBR1MAPK14 | |
| SCHEMBL29479307 | 0.77 | KDM4E (0.53) | KDM4ENOS1HSP90AA1TGFBR1MAPK14 | |
| SCHEMBL15066960 | 0.76 | ALDH1A1 (0.49) | MAPTKDM4ECYP3A4LMNAMEN1 | |
| Hydrochloric Acid SCHEMBL30345228 | 0.75 | KDM4E (0.52) | KDM4ENOS1HSP90AA1TGFBR1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0260642-A2 | Thiazolo [f]-fused hexahydroquinoline derivatives as dopaminergic agents | WARNER-LAMBERT COMPANY (US) | 1988-03-23 | — | — | EP | disclosed |