Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | AURKA | O14965 | 2/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10698666 | 0.89 | MEN1 (0.41) | BRD4MEN1KMT2AAURKAAURKB | |
| SCHEMBL10697806 | 0.88 | BRD4 (0.50) | BRD4MEN1KMT2AAURKAAURKB | |
| SCHEMBL10698669 | 0.87 | BRD4 (0.40) | BRD4MEN1KMT2AAURKAAURKB | |
| SCHEMBL10699071 | 0.87 | BRD4 (0.50) | BRD4MEN1KMT2AAURKAAURKB | |
| SCHEMBL10695172 | 0.86 | MEN1 (0.47) | BRD4MEN1KMT2AKDM4ENPC1 | |
| SCHEMBL10697218 | 0.86 | BRD4 (0.49) | BRD4MEN1KMT2AAURKAAURKB | |
| SCHEMBL10700226 | 0.84 | MEN1 (0.41) | BRD4MEN1KMT2AAURKAAURKB | |
| SCHEMBL10698656 | 0.83 | BRD4 (0.46) | BRD4MEN1KMT2AAURKAAURKB | |
| SCHEMBL10700863 | 0.82 | BRD4 (0.45) | BRD4MEN1KMT2AAURKAAURKB | |
| SCHEMBL10695690 | 0.81 | MEN1 (0.47) | BRD4MEN1KMT2AKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |