SCHEMBL10700780

SCHEMBL10700780

C=C[C@@]1(C)CC(=O)[C@]2(O)[C@@]3(C)[C@@H](O)CCC(C)(C)[C@@H]3[C@H](OC(=O)COc3ccccc3)[C@H](O)[C@@]2(C)O1

nearest known ligand 0.70

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ADCY1 Q08828 17/20 0.70
MAPK1 P28482 2/20 0.60
MLNR O43193 1/20 0.60
NR1I2 O75469 1/20 0.60
ADRA1A P35348 1/20 0.60
KCNH2 Q12809 1/20 0.60
MEN1 O00255 1/20 0.60
ALDH1A1 P00352 1/20 0.60
CYP3A4 P08684 1/20 0.60
CYP2C9 P11712 1/20 0.60
TSHR P16473 1/20 0.60
CYP2C19 P33261 1/20 0.60
KMT2A Q03164 1/20 0.60
GMNN O75496 1/20 0.59
BLM P54132 1/20 0.59
PMP22 Q01453 1/20 0.59
NPSR1 Q6W5P4 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7298674 0.89 MAPK1 (0.76) ADCY1MAPK1MLNRNR1I2ADRA1A
SCHEMBL7305520 0.87 MAPK1 (0.59) ADCY1MAPK1MLNRNR1I2ADRA1A
SCHEMBL7299730 0.87 ADCY1 (0.63) ADCY1MAPK1MLNRNR1I2ADRA1A
SCHEMBL7306939 0.86 MAPK1 (0.60) ADCY1MAPK1MLNRNR1I2ADRA1A
SCHEMBL11538072 0.86 ADCY1 (0.77) ADCY1MAPK1MLNRNR1I2ADRA1A
SCHEMBL9631733 0.85 ADCY1 (0.64) ADCY1MLNRNR1I2ADRA1AKCNH2
Hydrochloric Acid SCHEMBL10588367 0.84 ADCY1 (0.70) ADCY1MAPK1MLNRNR1I2ADRA1A
SCHEMBL8240684 0.83 ADCY1 (0.80) ADCY1MAPK1MLNRNR1I2ADRA1A
SCHEMBL11118724 0.83 ADCY1 (0.80) ADCY1MAPK1MLNRNR1I2ADRA1A
SCHEMBL27214139 0.83 ADCY1 (0.80) ADCY1MAPK1MLNRNR1I2ADRA1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0293814-A1 Mono- and polyhydroxyacyl derivatives of polyoxygenated labdanes, a process for their production and their use as drugs HOECHST AKTIENGESELLSCHAFT (DE) 1988-12-07 EP disclosed