ADCY1

Adenylate cyclase type 1 · Q08828 · ADCY1 on Sugi Atlas →

14,252 patent compounds predicted against ADCY1, 8,573 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL2232267	0.56	16/20
Colforsin (SCHEMBL4928)	1.00	14/20
Colforsin (SCHEMBL1517319)	1.00	14/20
SCHEMBL2233173	0.78	14/20
SCHEMBL2231230	0.77	14/20
SCHEMBL1482620	0.75	14/20
SCHEMBL1482696	0.72	14/20
SCHEMBL2232285	0.56	14/20
SCHEMBL219972	0.79	13/20
Hydrochloric Acid (SCHEMBL2230892)	0.78	13/20
Hydrochloric Acid (SCHEMBL1651080)	0.77	13/20
SCHEMBL801253	0.49	13/20
Hydrochloric Acid (SCHEMBL2232342)	0.70	12/20
SCHEMBL2615810	0.65	12/20
Colforsin (SCHEMBL2221354)	0.62	12/20
SCHEMBL905267	0.52	12/20
SCHEMBL1914588	0.53	10/20
SCHEMBL774750	0.65	9/20
SCHEMBL600566	0.46	9/20
SCHEMBL1919194	0.53	7/20

Clinical trials — most relevant to ADCY1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Clonidine vs. Dexmedetomidine in Agitated Delirium in Intensive Care Patients	PHASE4	UNKNOWN
The Phosphodiesterase 4 Inhibitor Roflumilast as an Adjunct to Antidepressants in Major Depressive Disorder Patients	PHASE1/PHASE2	WITHDRAWN
Pentoxifylline as an Adjunctive in Treatment of Negative Symptoms in Chronic Schizophrenia	PHASE1/PHASE2	COMPLETED
Theophylline Treatment for Pseudohypoparathyroidism - Children 2-12 Years Old	PHASE2	ACTIVE_NOT_RECRUITING
Discovery and Validation of Genetic Variants Affecting Microglial Activation in Alzheimer's Disease	PHASE2	ACTIVE_NOT_RECRUITING
Effects of Roflumilast on Insulin and Blood Sugar Levels in Prediabetic Overweight and Obese Individuals	PHASE1/PHASE2	COMPLETED
Title: Evaluation of a Novel PET Radioligand for Phosphodiesterase-4D (PDE4D)	PHASE1/PHASE2	COMPLETED
PET Whole Body Biodistribution and Test Retest Bain Imaging Studies Using a Phosphodiesterase 4 Inhibitor (R)-[11C]Rolipram	PHASE1	COMPLETED
Effect of Gene Variants on Dopamine Receptor Natriuretic Responses	PHASE1	UNKNOWN
Metformin's Effect on Glucagon-induced Glucose Production and Protein Metabolism.	PHASE1	COMPLETED
Caffeine Efficacy in ADCY5-related Dyskinesia	nan	UNKNOWN
Pilot Study on Caffeine Efficiency in ADCY5-related Dyskinesia	nan	COMPLETED
Assessment of ADCY5-related Movement Disorders With Motion SENSors	nan	COMPLETED
Stress and Treatment Response in Puerto Rican Children With Asthma	nan	COMPLETED
Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA	nan	RECRUITING
PACAP Induced Migraine Attacks in Patients With High and Low Genetic Load	nan	COMPLETED
Intravenous Terbutaline in Severe Status Asthmaticus	nan	UNKNOWN
The Effects of a Long-lasting Infusion of Vasoactive Intestinal Peptide (VIP) in Episodic Migraine Patients	nan	COMPLETED
Genetic Characterization of Parkinson's Disease	nan	COMPLETED
The Application of 68Ga-Pentixafor Alongside 68Ga-FAPI-04 PET/MR for Assessing Primary Aldosteronism.	nan	NOT_YET_RECRUITING
Phenotypic and Genotypic Studies in Congenital and Early Onset Ataxias	nan	COMPLETED
The Effects of Tailored Judo Training and Nutritional Counseling on Physical Fitness and Body Composition in Children With Autism: A Study Including Blood Morphology and Genetic Analysis	nan	COMPLETED
Identification of Genetic Basis of Atrioventricular Conduction Defects: From Congenital Forms to Degenerative Forms	nan	UNKNOWN
PACAP38´s (Pituitary Adenylate Cyclase-Activating Polypeptide) Headache Inducing Characteristics and Effects on the Cerebral Blood Flow	nan	COMPLETED
Genetic Analyses of Nonsyndromic and Syndromic Deafness in Pakistan	nan	ENROLLING_BY_INVITATION
Core Stability Exercises and Hereditary Ataxia	nan	COMPLETED
Effect of Intraperitoneal Bupivacaine with Dexmedotomidine or Fentanyl for Post-Operative Analgesia Following Laparoscopy in Pediatric Patients	nan	NOT_YET_RECRUITING
Biomarker Research in Inherited Movement Disorders	nan	RECRUITING
Poor Sleep and Inflammation in HIV-Infected Adults	nan	COMPLETED
Mechanisms of Inherited Retinal Dystrophies Using Whole Genome Sequencing and in Vitro and in Vivo Models	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a ADCY1 binder may also engage these)

Protein	Name	Similarity
O88444	—	1.000	O88444 →
P19754	—	1.000	P19754 →
P26770	—	0.998	P26770 →
Q91WF3	—	0.997	Q91WF3 →
ADCY2	Adenylate cyclase type 2	0.996	landscape →
P26769	—	0.995	P26769 →
ADCY7	Adenylate cyclase type 7 (EC 4.6.1.1) (ATP py	0.993	landscape →
ADCY4	Adenylate cyclase type 4 (EC 4.6.1.1) (ATP py	0.993	landscape →
Q80TL1	—	0.991	Q80TL1 →
ADCY3	Adenylate cyclase type 3	0.991	landscape →
P97490	—	0.990	P97490 →
P51829	—	0.988	P51829 →
Q29450	—	0.988	Q29450 →
P32870	—	0.986	P32870 →
Q03343	—	0.986	Q03343 →
Q1LZF7	—	0.986	Q1LZF7 →
P40146	—	0.985	P40146 →
ADCY8	Adenylate cyclase type 8	0.984	landscape →
P55203	—	0.984	P55203 →
ADCY6	Adenylate cyclase type 6 (EC 4.6.1.1) (ATP py	0.983	landscape →
Q9R101	—	0.983	Q9R101 →
Q8K337	—	0.983	Q8K337 →
O95838	—	0.983	O95838 →
Q6DCK1	—	0.982	Q6DCK1 →
P30804	—	0.982	P30804 →
B6ZK77	—	0.982	B6ZK77 →
P69744	—	0.982	P69744 →
O09127	—	0.982	O09127 →
Q9ERL9	—	0.982	Q9ERL9 →
Q9R186	—	0.982	Q9R186 →