Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA1 known ✓ | P02708 | 1/20 | 0.32 |
| ▸ | CHRNG known ✓ | P07510 | 1/20 | 0.32 |
| ▸ | CHRNB1 known ✓ | P11230 | 1/20 | 0.32 |
| ▸ | CHRND known ✓ | Q07001 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7056434 | 0.97 | — | — | |
| SCHEMBL23590797 | 0.73 | CHRNA1 (0.31) | CHRNA1CHRNGCHRNB1CHRNB2SLC6A2 | |
| SCHEMBL23771023 | 0.70 | — | — | |
| SCHEMBL6440724 | 0.67 | — | — | |
| Iodide SCHEMBL10709832 | 0.66 | — | — | |
| SCHEMBL20940082 | 0.63 | PDK1 (0.31) | — | |
| SCHEMBL23732291 | 0.63 | CHRNA1 (0.31) | CHRNA1CHRNGCHRNB1CHRNB2SLC6A2 | |
| Iodide SCHEMBL10706583 | 0.63 | CYP2D6 (0.31) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL10825994 | 0.57 | GAA (0.32) | — | |
| SCHEMBL82179 | 0.56 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4792224-A | SPIROOXAZOLIDINE-PYRIDOBENZOXAZINE OR NAPTHOXAZINE COMPOUNDS; LENS; RED | PPG INDUSTRIES, INC. (US) | 1988-12-20 | — | — | US | disclosed |