Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 4/20 | 0.67 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | GAA | P10253 | 5/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | GLA | P06280 | 3/20 | 0.47 |
| ▸ | CASP1 | P29466 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | CASP7 | P55210 | 1/20 | 0.47 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAD52 | P43351 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11112855 | 0.91 | AKT1 (0.69) | AKT1MAPTPTGS2KMT2AKDM4E | |
| SCHEMBL10639092 | 0.84 | AKT1 (0.60) | AKT1MAPTPTGS2KMT2AKDM4E | |
| SCHEMBL11105397 | 0.83 | AKT1 (0.45) | AKT1MAPTKDM4EALDH1A1GAA | |
| SCHEMBL2783197 | 0.81 | AKT1 (0.72) | AKT1MAPTPTGS2KMT2AKDM4E | |
| SCHEMBL2784941 | 0.81 | AKT1 (0.72) | AKT1MAPTPTGS2KMT2AKDM4E | |
| SCHEMBL2784350 | 0.81 | AKT1 (0.72) | AKT1MAPTPTGS2KMT2AKDM4E | |
| SCHEMBL15441431 | 0.80 | AKT1 (1.00) | AKT1MAPTPTGS2KMT2AKDM4E | |
| SCHEMBL11108601 | 0.78 | AKT1 (0.53) | AKT1MAPTPTGS2KMT2AKDM4E | |
| SCHEMBL11109592 | 0.78 | MAPT (0.62) | AKT1MAPTPTGS2KMT2AKDM4E | |
| SCHEMBL1146916 | 0.76 | MAPT (1.00) | AKT1MAPTKMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0129906-B1 | PHENOXYALKOXY-3,4-DIHYDRO-2H-1-BENZOPYRAN DERIVATIVES | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1988-06-08 | — | — | EP | disclosed |