Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 19/20 | 0.71 |
| ▸ | MMP3 | P08254 | 4/20 | 0.70 |
| ▸ | MMP2 | P08253 | 3/20 | 0.70 |
| ▸ | MMP9 | P14780 | 2/20 | 0.70 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.69 |
| ▸ | MMP7 | P09237 | 1/20 | 0.67 |
| ▸ | MMP8 | P22894 | 1/20 | 0.67 |
| ▸ | MMP13 | P45452 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28221950 | 0.89 | MMP1 (0.57) | MMP1MMP3MMP2MMP9ADAM17 | |
| SCHEMBL11119378 | 0.89 | MMP1 (0.58) | MMP1MMP3MMP2MMP9ADAM17 | |
| SCHEMBL28221952 | 0.89 | MMP1 (0.57) | MMP1MMP3MMP2MMP9ADAM17 | |
| SCHEMBL28222734 | 0.89 | MMP1 (0.58) | MMP1MMP3MMP2MMP9ADAM17 | |
| SCHEMBL28222730 | 0.89 | MMP1 (0.58) | MMP1MMP3MMP2MMP9ADAM17 | |
| SCHEMBL28860408 | 0.89 | MMP1 (0.57) | MMP1MMP3MMP2MMP9ADAM17 | |
| SCHEMBL28221966 | 0.89 | MMP1 (0.60) | MMP1MMP3MMP2MMP9ADAM17 | |
| SCHEMBL28222036 | 0.89 | MMP1 (0.60) | MMP1MMP3MMP2MMP9ADAM17 | |
| SCHEMBL28221962 | 0.89 | MMP1 (0.60) | MMP1MMP3MMP2MMP9ADAM17 | |
| SCHEMBL8162700 | 0.85 | MMP1 (0.71) | MMP1MMP3MMP2MMP9ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0126974-B1 | CARBOXYALKYL PEPTIDE DERIVATIVES | G.D. Searle & Co. (US) | 1988-06-15 | — | — | EP | disclosed |
| US-4568666-A | COLLAGENASE INHIBITORS, ANTIARTJRITIC AGENTS | G. D. SEARLE & CO. (US) | 1986-02-04 | — | — | US | disclosed |
| EP-0159396-A2 | Carboxyalkyl peptide derivatives | G.D. Searle & Co. (US) | 1985-10-30 | — | — | EP | disclosed |
| US-4511504-A | COLLAGENASE INHIBITORS | G.D. SEARLE & CO. (US) | 1985-04-16 | — | — | US | disclosed |
| EP-0126974-A1 | Carboxyalkyl peptide derivatives | G.D. Searle & Co. (US) | 1984-12-05 | — | — | EP | disclosed |