Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 14/20 | 0.84 |
| ▸ | PDE4B | Q07343 | 14/20 | 0.84 |
| ▸ | PDE4C | Q08493 | 14/20 | 0.84 |
| ▸ | PDE4D | Q08499 | 14/20 | 0.84 |
| ▸ | ACHE | P22303 | 2/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | KHK | P50053 | 1/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL292710 | 0.91 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DACHE | |
| SCHEMBL291798 | 0.91 | PDE4A (0.96) | PDE4APDE4BPDE4CPDE4DACHE | |
| SCHEMBL29824397 | 0.91 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DACHE | |
| SCHEMBL10713846 | 0.89 | PDE4A (0.84) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10870557 | 0.88 | PDE4A (0.65) | PDE4APDE4BPDE4CPDE4DACHE | |
| SCHEMBL10707518 | 0.87 | PDE4A (0.81) | PDE4APDE4BPDE4CPDE4DACHE | |
| SCHEMBL11013543 | 0.87 | PDE4A (0.72) | PDE4APDE4BPDE4CPDE4DACHE | |
| SCHEMBL10705537 | 0.85 | PDE4A (0.65) | PDE4APDE4BPDE4CPDE4DACHE | |
| SCHEMBL10707459 | 0.85 | PDE4A (0.63) | PDE4APDE4BPDE4CPDE4DACHE | |
| SCHEMBL10705322 | 0.81 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0134922-B1 | 2-PIPERAZINO-PTERIDINES, PROCESSES FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THESE COMPOUNDS | Dr. Karl Thomae GmbH (DE) | 1988-12-14 | — | — | EP | disclosed |
| US-4560685-A | 2-Piperazino-pteridines useful as antithrombotics and antimetastatics | DR. KARL THOMAE GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1985-12-24 | — | — | US | disclosed |
| EP-0134922-A1 | 2-Piperazino-pteridines, processes for their preparation and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-03-27 | — | — | EP | disclosed |