Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 15/20 | 0.96 |
| ▸ | PDE4B | Q07343 | 15/20 | 0.96 |
| ▸ | PDE4C | Q08493 | 15/20 | 0.96 |
| ▸ | PDE4D | Q08499 | 15/20 | 0.96 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.45 |
| ▸ | KHK | P50053 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29824397 | 0.98 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DACHE | |
| SCHEMBL292710 | 0.98 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DACHE | |
| SCHEMBL10705672 | 0.91 | PDE4A (0.84) | PDE4APDE4BPDE4CPDE4DACHE | |
| SCHEMBL10713846 | 0.91 | PDE4A (0.84) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10707518 | 0.90 | PDE4A (0.81) | PDE4APDE4BPDE4CPDE4DACHE | |
| SCHEMBL291770 | 0.84 | PDE4A (0.73) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL11013543 | 0.84 | PDE4A (0.72) | PDE4APDE4BPDE4CPDE4DACHE | |
| SCHEMBL3539405 | 0.83 | PDE4A (0.75) | PDE4APDE4BPDE4CPDE4DACHE | |
| SCHEMBL3538019 | 0.83 | PDE4A (0.75) | PDE4APDE4BPDE4CPDE4DACHE | |
| SCHEMBL5201775 | 0.83 | PDE4A (0.86) | PDE4APDE4BPDE4CPDE4DACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029600-B1 | SUBSTITUTED PTERIDINES SUBSTITUTED WITH A FOUR-MEMBERED HETEROCYCLE | BOEHRINGER INGELHEIM INT (DE) | 2012-03-14 | — | — | EP | disclosed |
| EP-2029600-B1 | SUBSTITUTED PTERIDINES SUBSTITUTED WITH A FOUR-MEMBERED HETEROCYCLE | BOEHRINGER INGELHEIM INT (DE) | 2012-03-14 | — | — | EP | disclosed |
| US-20100234347-A1 | Substituted Pteridines substituted with a Four-Membered Heterocycle | BOEHRINGER INGELHEIM INTERNATIONL GMBH (DE) | 2010-09-16 | — | — | US | disclosed |
| US-20100234347-A1 | Substituted Pteridines substituted with a Four-Membered Heterocycle | BOEHRINGER INGELHEIM INTERNATIONL GMBH (DE) | 2010-09-16 | — | — | US | disclosed |
| US-20100234347-A1 | Substituted Pteridines substituted with a Four-Membered Heterocycle | BOEHRINGER INGELHEIM INTERNATIONL GMBH (DE) | 2010-09-16 | — | — | US | disclosed |
| WO-2007135027-A1 | SUBSTITUTED PTERIDINES SUBSTITUTED WITH A FOUR-MEMBERED HETEROCYCLE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-11-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100234347-A1 | Substituted Pteridines substituted with a Four-Membered Heterocycle | UACA, LTC4S, PMP22 | PDE4A 1509/4885PDE4B 1446/4885PDE4C 1569/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.