Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHGDH | O43175 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CPT2 | P23786 | 1/20 | 0.40 |
| ▸ | CPT1A | P50416 | 1/20 | 0.40 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2485998 | 0.92 | MAPT (0.46) | PHGDHMAPTGAAHTTNPSR1 | |
| SCHEMBL10714574 | 0.90 | MAPT (0.40) | MAPTGAAHTTTP53NPC1 | |
| SCHEMBL10711637 | 0.90 | NPC1 (0.48) | MAPTGAAHTTNPSR1POLB | |
| SCHEMBL10700306 | 0.89 | MAPT (0.51) | MAPTGAAPOLBNPC1RAB9A | |
| SCHEMBL10711757 | 0.89 | MAPT (0.40) | MAPTGAAHTTNPC1RAB9A | |
| SCHEMBL10709119 | 0.89 | MAPT (0.41) | MAPTGAAHTTPOLBNPC1 | |
| SCHEMBL10704419 | 0.89 | MAPT (0.41) | MAPTGAAHTTNPSR1NPC1 | |
| SCHEMBL10711705 | 0.87 | AURKA (0.36) | MAPTGAAHTTNPSR1TP53 | |
| SCHEMBL10710846 | 0.87 | TP53 (0.35) | MAPTGAAHTTNPSR1TP53 | |
| SCHEMBL2516093 | 0.86 | HTT (0.39) | MAPTGAAHTTNPSR1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |