Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.51 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | CRHBP | P24387 | 1/20 | 0.48 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | SCD | O00767 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10709260 | 0.93 | MAPT (0.49) | MAPTNPC1RAB9AMAPK1SMN1; SMN2 | |
| SCHEMBL10696183 | 0.91 | MAPT (0.51) | MAPTNPC1RAB9AMAPK1SMN1; SMN2 | |
| SCHEMBL10700803 | 0.91 | MAPT (0.48) | MAPTNPC1RAB9AMAPK1SMN1; SMN2 | |
| SCHEMBL10699942 | 0.90 | MAPT (0.51) | MAPTNPC1RAB9AMAPK1SMN1; SMN2 | |
| SCHEMBL10700798 | 0.89 | LMNA (0.48) | MAPTNPC1RAB9AMAPK1SMN1; SMN2 | |
| SCHEMBL10708448 | 0.89 | PHGDH (0.47) | MAPTNPC1RAB9AMAPK1KMT2A | |
| SCHEMBL10714574 | 0.89 | MAPT (0.40) | MAPTNPC1RAB9AMAPK1SMN1; SMN2 | |
| SCHEMBL2485964 | 0.88 | LMNA (0.47) | MAPTNPC1RAB9AMAPK1SMN1; SMN2 | |
| SCHEMBL10699123 | 0.88 | MAPT (0.52) | MAPTNPC1RAB9AMAPK1SMN1; SMN2 | |
| SCHEMBL10711637 | 0.88 | NPC1 (0.48) | MAPTNPC1RAB9AMAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |